Literature DB >> 16831917

Molecular mechanism of the life and death of the osteoclast.

Sakae Tanaka1, Tsuyoshi Miyazaki, Akira Fukuda, Toru Akiyama, Yuho Kadono, Hidetoshi Wakeyama, Shinjiro Kono, Shinya Hoshikawa, Masaki Nakamura, Yasushi Ohshima, Atsuhiko Hikita, Ichiro Nakamura, Kozo Nakamura.   

Abstract

The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.

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Year:  2006        PMID： 16831917     DOI： 10.1196/annals.1346.020

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  17 in total

1.  Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling.

Authors:  Bokyung Sung; Sung-Gook Cho; Mingyao Liu; Bharat B Aggarwal
Journal:  Int J Cancer       Date:  2011-03-11       Impact factor: 7.396

Review 2.  Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts.

Authors:  Brendan F Boyce
Journal:  J Bone Miner Res       Date:  2013-04       Impact factor: 6.741

3.  Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival.

Authors:  Natsuko Tanabe; Benjamin D Wheal; Jiyun Kwon; Hong H Chen; Ryan P P Shugg; Stephen M Sims; Harvey A Goldberg; S Jeffrey Dixon
Journal:  J Biol Chem       Date:  2011-09-22       Impact factor: 5.157

Review 4.  Advances in the regulation of osteoclasts and osteoclast functions.

Authors:  B F Boyce
Journal:  J Dent Res       Date:  2013-08-01       Impact factor: 6.116

Review 5.  Regulation of osteoclast-mediated bone resorption by microRNA.

Authors:  Ling Ji; Xinyi Li; Shushu He; Song Chen
Journal:  Cell Mol Life Sci       Date:  2022-05-10       Impact factor: 9.261

6.  Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation.

Authors:  Long-gang He; Xiang-lian Li; Xiang-zhou Zeng; Heng Duan; Song Wang; Lin-sheng Lei; Xiao-juan Li; Shu-wen Liu
Journal:  Acta Pharmacol Sin       Date:  2013-12-23       Impact factor: 6.150

Review 7.  Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions.

Authors:  Robert Coleman; Janet Brown; Evangelos Terpos; Allan Lipton; Matthew R Smith; Richard Cook; Pierre Major
Journal:  Cancer Treat Rev       Date:  2008-06-24       Impact factor: 12.111

8.  Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption.

Authors:  Tsuyoshi Miyazaki; Mitsuyasu Iwasawa; Tomoki Nakashima; Shuuichi Mori; Kazuhiro Shigemoto; Hiroaki Nakamura; Hideki Katagiri; Hiroshi Takayanagi; Sakae Tanaka
Journal:  J Biol Chem       Date:  2012-09-17       Impact factor: 5.157

9.  Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling.

Authors:  Dinesh Thummuri; V G M Naidu; Pradip Chaudhari
Journal:  J Mol Med (Berl)       Date:  2017-07-04       Impact factor: 4.599

10.  Sustained mitogen-activated protein kinase activation with Aggregatibacter actinomycetemcomitans causes inflammatory bone loss.

Authors:  J Dunmyer; B Herbert; Q Li; R Zinna; K Martin; H Yu; K L Kirkwood
Journal:  Mol Oral Microbiol       Date:  2012-07-11       Impact factor: 3.563
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