Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238.

Literature DB >> 16830891

Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238.

Seong-Yun Jeong¹, Hee Jae Shin, Tae Sik Kim, Hyi-Seung Lee, Song-kyu Park, Hwan Mook Kim.

Abstract

A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2006 PMID： 16830891 DOI： 10.1038/ja.2006.33

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

Keyword Cloud
Cited

12 in total

1. Bioactive compounds from marine actinomycetes.

Authors: Renu Solanki; Monisha Khanna; Rup Lal
Journal: Indian J Microbiol Date: 2009-01-08 Impact factor: 2.461

2. Research on marine actinobacteria in India.

Authors: K Sivakumar; Maloy Kumar Sahu; T Thangaradjou; L Kannan
Journal: Indian J Microbiol Date: 2007-10-04 Impact factor: 2.461

Review 3. Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.

Authors: Robin K Pettit
Journal: Mar Biotechnol (NY) Date: 2010-05-01 Impact factor: 3.619

10. A tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation tools.

Authors: Joydeep Mukherjee; Lyndon E Llewellyn; Elizabeth A Evans-Illidge
Journal: Mar Drugs Date: 2008-10-13 Impact factor: 5.118

Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238.

1. Bioactive compounds from marine actinomycetes.

2. Research on marine actinobacteria in India.

Review 3. Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.

4. Antimicrobial potential of deep surface sediment associated bacteria from the Sea of Japan.

Review 5. Antitumor compounds from marine actinomycetes.

6. Marine Bacterial Compounds Evaluated by In Silico Studies as Antipsychotic Drugs Against Schizophrenia.

Review 7. Deep Sea Actinomycetes and Their Secondary Metabolites.

8. Diversity, Bioactivity Profiling and Untargeted Metabolomics of the Cultivable Gut Microbiota of Ciona intestinalis.

Review 9. Secondary metabolites and biodiversity of actinomycetes.

10. A tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation tools.