| Literature DB >> 16828759 |
Mario Torrado1, Beatriz Nespereira, Yolanda Bouzamayor, Alberto Centeno, Eduardo López, Alexander T Mikhailov.
Abstract
Diastolic heart failure (DHF) was produced in 6-day-old piglets by intravenous administration of Doxorubicin, and ANKRD1 protein and mRNA levels were determined in atrial (A) and ventricular (V) chambers of failing vs control hearts. In controls, ANKRD1 showed a left-right (L-R) asymmetric distribution with protein levels 2-fold higher in the LA as compared to the RA, and 8-fold higher in the LV than the RV. In failing hearts, ANKRD1 levels were augmented about 2-fold in each ventricle but equally reduced in both atria as compared to controls. ANKRD1 downregulation in atria is discussed as a process associated with advanced DHF.Entities:
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Year: 2006 PMID： 16828759 DOI： 10.1016/j.febslet.2006.06.073
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124