| Literature DB >> 16828720 |
Sokreine Suon1, Ming Yang2, Lorraine Iacovitti3.
Abstract
Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neurons appeared to survive transplantation, there were abundant GABA neurons present in the graft. By 4 weeks, however, all cells had died. Finding ways to prolong survival and promote the appropriate neurotransmitter phenotype is essential if hMSCs are to be clinically useful.Entities:
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Year: 2006 PMID： 16828720 PMCID： PMC1949017 DOI： 10.1016/j.brainres.2006.05.109
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252