| Literature DB >> 16828716 |
Asuka Kaizaki1, Sachiko Tanaka, Kumiko Ishige, Satoshi Numazawa, Takemi Yoshida.
Abstract
To investigate the role of heme oxygenase (HO) isozymes, we used siRNA technology to suppress HO-1 expression. HO-1 siRNA-transfected HT22 cells were vulnerable to hydrogen peroxide- and 4-hydroxynonenal-induced cytotoxicity. Biliverdin and bilirubin, degradative products of heme catalyzed by HO, protected HT22 cells from the insult of these oxidative stressors. These results suggest that inducible HO-1 plays a protective role against oxidative stress in HT22 cells.Entities:
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Year: 2006 PMID： 16828716 DOI： 10.1016/j.brainres.2006.06.011
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252