BACKGROUND: Although QRS duration is known to be a predictor of mortality in patients with left ventricular dysfunction, our purpose was to evaluate the prognostic power of computer-measured QRS duration in a general medical population. METHODS: Analyses were performed on the first electrocardiogram digitally recorded on 46,933 consecutive patients at the Palo Alto Veterans Affairs Medical Center between 1987 and 2000. Patients with electrocardiograms exhibiting Wolff-Parkinson-White were excluded (n = 44), and those with bundle branch block or electronic pacing were considered separately, leaving 44,280 patients for analysis (mean age 56 +/- 15 years; 90% were males). There were 3659 (8.3%) cardiovascular deaths (mean follow-up of 6.0 +/- 3.8 years). RESULTS: A survival plot showed significant separation according to a QRS duration score. After adjustment in the Cox model for age, gender, and heart rate, the QRS duration score was a strong independent predictor of cardiovascular mortality. For every 10-ms increase in QRS duration, there was an 18% increase in cardiovascular risk. The results were similar in patients with an abnormal electrocardiogram, a bundle branch block, and a paced rhythm. CONCLUSION: Quantitative QRS duration was a significant and independent predictor of cardiovascular mortality in a general medical population.
BACKGROUND: Although QRS duration is known to be a predictor of mortality in patients with left ventricular dysfunction, our purpose was to evaluate the prognostic power of computer-measured QRS duration in a general medical population. METHODS: Analyses were performed on the first electrocardiogram digitally recorded on 46,933 consecutive patients at the Palo Alto Veterans Affairs Medical Center between 1987 and 2000. Patients with electrocardiograms exhibiting Wolff-Parkinson-White were excluded (n = 44), and those with bundle branch block or electronic pacing were considered separately, leaving 44,280 patients for analysis (mean age 56 +/- 15 years; 90% were males). There were 3659 (8.3%) cardiovascular deaths (mean follow-up of 6.0 +/- 3.8 years). RESULTS: A survival plot showed significant separation according to a QRS duration score. After adjustment in the Cox model for age, gender, and heart rate, the QRS duration score was a strong independent predictor of cardiovascular mortality. For every 10-ms increase in QRS duration, there was an 18% increase in cardiovascular risk. The results were similar in patients with an abnormal electrocardiogram, a bundle branch block, and a paced rhythm. CONCLUSION: Quantitative QRS duration was a significant and independent predictor of cardiovascular mortality in a general medical population.
Authors: Martial M Massin; Sophie G Malekzadeh-Milani; Stefan Schifflers; Hugues Dessy; Thierry Verbeet Journal: Ann Noninvasive Electrocardiol Date: 2011-10 Impact factor: 1.468
Authors: Michel Zuber; Christine H Attenhofer Jost; Peter Kipfer; Sean P Collins; Frank Michota; W Frank Peacock Journal: Ann Noninvasive Electrocardiol Date: 2007-10 Impact factor: 1.468
Authors: Edmond M Cronin; Frank M Bogun; Philippe Maury; Petr Peichl; Minglong Chen; Narayanan Namboodiri; Luis Aguinaga; Luiz Roberto Leite; Sana M Al-Khatib; Elad Anter; Antonio Berruezo; David J Callans; Mina K Chung; Phillip Cuculich; Andre d'Avila; Barbara J Deal; Paolo Della Bella; Thomas Deneke; Timm-Michael Dickfeld; Claudio Hadid; Haris M Haqqani; G Neal Kay; Rakesh Latchamsetty; Francis Marchlinski; John M Miller; Akihiko Nogami; Akash R Patel; Rajeev Kumar Pathak; Luis C Saenz Morales; Pasquale Santangeli; John L Sapp; Andrea Sarkozy; Kyoko Soejima; William G Stevenson; Usha B Tedrow; Wendy S Tzou; Niraj Varma; Katja Zeppenfeld Journal: J Interv Card Electrophysiol Date: 2020-10 Impact factor: 1.900
Authors: Vincenzo Macri; Jennifer A Brody; Dan E Arking; William J Hucker; Xiaoyan Yin; Honghuang Lin; Robert W Mills; Moritz F Sinner; Steven A Lubitz; Ching-Ti Liu; Alanna C Morrison; Alvaro Alonso; Ning Li; Vadim V Fedorov; Paul M Janssen; Joshua C Bis; Susan R Heckbert; Elena V Dolmatova; Thomas Lumley; Colleen M Sitlani; L Adrienne Cupples; Sara L Pulit; Christopher Newton-Cheh; John Barnard; Jonathan D Smith; David R Van Wagoner; Mina K Chung; Gus J Vlahakes; Christopher J O'Donnell; Jerome I Rotter; Kenneth B Margulies; Michael P Morley; Thomas P Cappola; Emelia J Benjamin; Donna Muzny; Richard A Gibbs; Rebecca D Jackson; Jared W Magnani; Caroline N Herndon; Stephen S Rich; Bruce M Psaty; David J Milan; Eric Boerwinkle; Peter J Mohler; Nona Sotoodehnia; Patrick T Ellinor Journal: Circ Genom Precis Med Date: 2018-05
Authors: Marco V Perez; Frederick E Dewey; Swee Y Tan; Jonathan Myers; Victor F Froelicher Journal: Ann Noninvasive Electrocardiol Date: 2009-01 Impact factor: 1.468