Literature DB >> 16828168

Astroglial cells in primary culture: a valid model to study Neospora caninum infection in the CNS.

A M Pinheiro1, S L Costa, S M Freire, M A O Almeida, M Tardy, R El Bachá, M F D Costa.   

Abstract

The protozoan Neospora caninum has a veterinary importance because it causes abortion in cattle and neuromuscular alterations in dogs. We infected rat astrocytes, in vitro, with different concentrations of N. caninum. Astrocytes responded to infection by producing the pro-inflammatory cytokine TNF-alpha and the neurotoxic-free radical NO, 24 and 72 h post-infection. These data suggest that astrocytes, which are essential for brain function, are targets for the parasite and this represents a practical and valid model to study the effects of N. caninum on the CNS.

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Year:  2006        PMID： 16828168     DOI： 10.1016/j.vetimm.2006.05.006

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  7 in total

1.  Indoleamine 2,3-dioxygenase is involved in defense against Neospora caninum in human and bovine cells.

Authors:  Katrin Spekker; Markus Czesla; Vanessa Ince; Kathrin Heseler; Silvia K Schmidt; Gereon Schares; Walter Däubener
Journal:  Infect Immun       Date:  2009-07-20       Impact factor: 3.441

2.  Flavonoids modulate the proliferation of Neospora caninum in glial cell primary cultures.

Authors:  Rosan Barbosa de Matos; Suzana Braga-de-Souza; Bruno Pena Seara Pitanga; Victor Diógenes Amaral da Silva; Erica Etelvina Viana de Jesus; Alexandre Morales Pinheiro; Maria de Fátima Dias Costa; Ramon dos Santos El-Bacha; Cátia Suse de Oliveira Ribeiro; Silvia Lima Costa
Journal:  Korean J Parasitol       Date:  2014-12-23       Impact factor: 1.341

3.  Role of IFN-γ and LPS on neuron/glial co-cultures infected by Neospora caninum.

Authors:  Erica Etelvina Viana De Jesus; Alex Barbosa Dos Santos; Catia Suse Oliveira Ribeiro; Alexandre Moraes Pinheiro; Songeli Menezes Freire; Ramon Santos El-Bachá; Silvia Lima Costa; Maria de Fatima Dias Costa
Journal:  Front Cell Neurosci       Date:  2014-10-27       Impact factor: 5.505

Review 4.  From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or Combating Neospora caninum Infection in Different Susceptible Hosts.

Authors:  Ragab M Fereig; Yoshifumi Nishikawa
Journal:  Pathogens       Date:  2020-05-16

Review 5.  Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum.

Authors:  Ana Elisa Del'Arco; Deivison Silva Argolo; Gilles Guillemin; Maria de Fátima Dias Costa; Silvia Lima Costa; Alexandre Moraes Pinheiro
Journal:  Front Immunol       Date:  2022-01-26       Impact factor: 7.561

6.  Activation of the Kynurenine Pathway and Production of Inflammatory Cytokines by Astrocytes and Microglia Infected With Neospora caninum.

Authors:  Deivison Silva Argolo; Julita Maria Pereira Borges; Luciana Dos Santos Freitas; Gizelle Alves Pina; Maria Socorro Grangeiro; Victor Diógenes Amaral da Silva; Alexandre Moraes Pinheiro; Rodrigo Souza Conceição; Alexsandro Branco; Gilles Guillemin; Silvia Lima Costa; Maria de Fátima Dias Costa
Journal:  Int J Tryptophan Res       Date:  2022-01-30

7.  Susceptibility to experimental infection of the invertebrate locusts (Schistocerca gregaria) with the apicomplexan parasite Neospora caninum.

Authors:  Mamdowh M Alkurashi; Sean T May; Kenny Kong; Jaume Bacardit; David Haig; Hany M Elsheikha
Journal:  PeerJ       Date:  2014-12-02       Impact factor: 2.984
  7 in total

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