Literature DB >> 1682806

A DNA sequence (LD1) which occurs in several genomic organizations in Leishmania.

C A Tripp1, P J Myler, K Stuart.   

Abstract

Leishmania DNA 1 (LD1) is a 27.5-kb sequence that occurs in all 91 stocks of twelve New and Old World Leishmania species examined; related sequences are present in some other kinetoplastid species. LD1 has no homology to several DNA sequences that are amplified in drug-resistant Leishmania. LD1 occurs in 3 different genomic organizations in Leishmania, depending on the stock. It is present within large (1.5-2 megabase) chromosomes in all stocks, and 74 stocks contain only this form. In 12 other stocks, LD1 also occurs in smaller (less than 550 kb) chromosomes, some of which are multicopy. Five stocks contain LD1 in multicopy circular DNA molecules in addition to the sequences found in the larger chromosome(s). Restriction fragment length polymorphisms of LD1 sequences correlate with taxonomic grouping, suggsting that LD1 is an endogenous sequence.

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Year:  1991        PMID： 1682806     DOI： 10.1016/0166-6851(91)90174-5

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  11 in total

1.  Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania.

Authors:  P Dubessay; C Ravel; P Bastien; M F Lignon; B Ullman; M Pagès; C Blaineau
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

2.  Global genome diversity of the Leishmania donovani complex.

Authors:  Susanne U Franssen; Caroline Durrant; Olivia Stark; Bettina Moser; Tim Downing; Hideo Imamura; Jean-Claude Dujardin; Mandy J Sanders; Isabel Mauricio; Michael A Miles; Lionel F Schnur; Charles L Jaffe; Abdelmajeed Nasereddin; Henk Schallig; Matthew Yeo; Tapan Bhattacharyya; Mohammad Z Alam; Matthew Berriman; Thierry Wirth; Gabriele Schönian; James A Cotton
Journal:  Elife       Date:  2020-03-25       Impact factor: 8.140

3.  Telomerase in kinetoplastid parasitic protozoa.

Authors:  M I Cano; J M Dungan; N Agabian; E H Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

4.  Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus.

Authors:  M J Lodes; G Merlin; T deVos; A Ghosh; R Madhubala; P J Myler; K Stuart
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272

5.  Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae.

Authors:  K Grondin; G Roy; M Ouellette
Journal:  Mol Cell Biol       Date:  1996-07       Impact factor: 4.272

6.  Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.

Authors:  F J Gueiros-Filho; S M Beverley
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

7.  Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani.

Authors:  S Hanson; S M Beverley; W Wagner; B Ullman
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

Review 8.  Drug resistance analysis by next generation sequencing in Leishmania.

Authors:  Philippe Leprohon; Christopher Fernandez-Prada; Élodie Gazanion; Rubens Monte-Neto; Marc Ouellette
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-09-22       Impact factor: 4.077

9.  Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania.

Authors:  Jean-Michel Ubeda; Frédéric Raymond; Angana Mukherjee; Marie Plourde; Hélène Gingras; Gaétan Roy; Andréanne Lapointe; Philippe Leprohon; Barbara Papadopoulou; Jacques Corbeil; Marc Ouellette
Journal:  PLoS Biol       Date:  2014-05-20       Impact factor: 8.029

10.  Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

Authors:  Jean-Michel Ubeda; Danielle Légaré; Frédéric Raymond; Amin Ahmed Ouameur; Sébastien Boisvert; Philippe Rigault; Jacques Corbeil; Michel J Tremblay; Martin Olivier; Barbara Papadopoulou; Marc Ouellette
Journal:  Genome Biol       Date:  2008-07-18       Impact factor: 13.583
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