| Literature DB >> 16827570 |
Takayuki Doi1, Yoichiro Hoshina, Hiroyuki Mogi, Yoshifumi Yamada, Takashi Takahashi.
Abstract
A 24-member combinatorial library based on the structure of aeruginosin 298-A (1a) was synthesized utilizing solid-phase, and their inhibitory activity against trypsin was evaluated. Among the library, we found that D-Hpla-D-Leu-L-Choi-Agma (1h) is 300 times more potent than the parent natural product 1a.Entities:
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Year: 2006 PMID： 16827570 DOI： 10.1021/cc0600270
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766