Literature DB >> 16826543

Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase.

Anne Roberts1, Jeffrey G Pelton, David E Wemmer.   

Abstract

The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function. Copyright 2006 John Wiley & Sons, Ltd.

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Year:  2006        PMID： 16826543     DOI： 10.1002/mrc.1823

Source DB:  PubMed          Journal:  Magn Reson Chem        ISSN： 0749-1581            Impact factor:   2.447


  10 in total

1.  Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage.

Authors:  Giuseppe Perugino; Antonella Vettone; Giuseppina Illiano; Anna Valenti; Maria C Ferrara; Mosè Rossi; Maria Ciaramella
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

2.  Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.

Authors:  Qingming Fang; Anne M Noronha; Sebastian P Murphy; Christopher J Wilds; Julie L Tubbs; John A Tainer; Goutam Chowdhury; F Peter Guengerich; Anthony E Pegg
Journal:  Biochemistry       Date:  2008-09-20       Impact factor: 3.162

3.  Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.

Authors:  James M Aramini; Julie L Tubbs; Sreenivas Kanugula; Paolo Rossi; Asli Ertekin; Melissa Maglaqui; Keith Hamilton; Colleen T Ciccosanti; Mei Jiang; Rong Xiao; Ta-Tsen Soong; Burkhard Rost; Thomas B Acton; John K Everett; Anthony E Pegg; John A Tainer; Gaetano T Montelione
Journal:  J Biol Chem       Date:  2010-03-08       Impact factor: 5.157

Review 4.  Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.

Authors:  Antonella Vettone; Giuseppe Perugino; Mosè Rossi; Anna Valenti; Maria Ciaramella
Journal:  Extremophiles       Date:  2014-08-08       Impact factor: 2.395

Review 5.  DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.

Authors:  Julie L Tubbs; Anthony E Pegg; John A Tainer
Journal:  DNA Repair (Amst)       Date:  2007-05-07

6.  Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.

Authors:  Giuseppe Perugino; Riccardo Miggiano; Mario Serpe; Antonella Vettone; Anna Valenti; Samarpita Lahiri; Franca Rossi; Mosè Rossi; Menico Rizzi; Maria Ciaramella
Journal:  Nucleic Acids Res       Date:  2015-07-30       Impact factor: 16.971

7.  Biochemical and structural studies of the Mycobacterium tuberculosis O6-methylguanine methyltransferase and mutated variants.

Authors:  Riccardo Miggiano; Valentina Casazza; Silvia Garavaglia; Maria Ciaramella; Giuseppe Perugino; Menico Rizzi; Franca Rossi
Journal:  J Bacteriol       Date:  2013-04-05       Impact factor: 3.490

Review 8.  Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.

Authors:  Riccardo Miggiano; Anna Valenti; Franca Rossi; Menico Rizzi; Giuseppe Perugino; Maria Ciaramella
Journal:  Int J Mol Sci       Date:  2017-12-05       Impact factor: 5.923

Review 9.  O6-alkylguanine-DNA Alkyltransferases in Microbes Living on the Edge: From Stability to Applicability.

Authors:  Rosanna Mattossovich; Rosa Merlo; Riccardo Miggiano; Anna Valenti; Giuseppe Perugino
Journal:  Int J Mol Sci       Date:  2020-04-20       Impact factor: 5.923

Review 10.  Targeting Genome Integrity in Mycobacterium Tuberculosis: From Nucleotide Synthesis to DNA Replication and Repair.

Authors:  Riccardo Miggiano; Castrese Morrone; Franca Rossi; Menico Rizzi
Journal:  Molecules       Date:  2020-03-07       Impact factor: 4.411
  10 in total

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