Literature DB >> 16826428

Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR.

Rajib Rajhans1, Ratna K Vadlamudi.   

Abstract

Estradiol (E2) and estrogen receptor (ER) signaling have been implicated in the development and progression of several cancers. Emerging evidence suggests that the status of ER coregulators in tumor cells plays an important role in hormonal responsiveness and tumor progression. Proline, glutamic acid, and leucine-rich protein-1 (PELP1/MNAR)-a novel ER coactivator that plays an essential role in the ER's actions and its expression-is deregulated in several hormonal responsive cancers. The precise function of PELP1/MNAR in cancer progression remains unclear, but PELP1 appears to function as a scaffolding protein, coupling ER with several proteins that are implicated in oncogenesis. Emerging evidence suggests that PELP1/MNAR increases E2-mediated cell proliferation and participates in E2-mediated tumorigenesis and metastasis.

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Year:  2006        PMID： 16826428     DOI： 10.1007/s10585-006-9019-9

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  29 in total

1.  Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.

Authors:  Bramanandam Manavathi; Sujit S Nair; Rui-An Wang; Rakesh Kumar; Ratna K Vadlamudi
Journal:  Cancer Res       Date:  2005-07-01       Impact factor: 12.701

2.  Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons.

Authors:  Mohammad M Khan; Martin Hadman; Chandramohan Wakade; Liesl M De Sevilla; Krishnan M Dhandapani; Virendra B Mahesh; Ratna K Vadlamudi; Darrell W Brann
Journal:  Endocrinology       Date:  2005-09-01       Impact factor: 4.736

3.  9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

Authors:  Rajesh R Singh; Anupama E Gururaj; Ratna K Vadlamudi; Rakesh Kumar
Journal:  J Biol Chem       Date:  2006-03-30       Impact factor: 5.157

Review 4.  Nontransgenic models of breast cancer.

Authors:  G H Heppner; F R Miller; P M Shekhar
Journal:  Breast Cancer Res       Date:  2000-08-04       Impact factor: 6.466

5.  Developmental expression of MNAR mRNA in the mouse brain.

Authors:  Justyna Pawlak; Cordian Beyer
Journal:  Cell Tissue Res       Date:  2005-04-22       Impact factor: 5.249

6.  Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK.

Authors:  Suresh K Rayala; Petra den Hollander; Seetharaman Balasenthil; Poonam R Molli; Andrew J Bean; Ratna K Vadlamudi; Rui-An Wang; Rakesh Kumar
Journal:  J Biol Chem       Date:  2005-12-12       Impact factor: 5.157

7.  Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets.

Authors:  Ratna K Vadlamudi; Seetharaman Balasenthil; Aysegul A Sahin; Merrill Kies; Randal S Weber; Rakesh Kumar; Adel K El-Naggar
Journal:  Hum Pathol       Date:  2005-06       Impact factor: 3.466

8.  Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.

Authors:  Frank Barletta; Chi-Wai Wong; Chris McNally; Barry S Komm; Benita Katzenellenbogen; Boris J Cheskis
Journal:  Mol Endocrinol       Date:  2004-02-12

9.  MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions.

Authors:  Sandip K Mishra; Abhijit Mazumdar; Ratna K Vadlamudi; Feng Li; Rui-An Wang; Wei Yu; V Craig Jordan; Richard J Santen; Rakesh Kumar
Journal:  J Biol Chem       Date:  2003-03-14       Impact factor: 5.157

10.  Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway.

Authors:  Sandip K Mishra; Amjad H Talukder; Anupama E Gururaj; Zhibo Yang; Rajesh R Singh; My G Mahoney; Clara Francí; Ratna K Vadlamudi; Rakesh Kumar
Journal:  J Biol Chem       Date:  2004-05-28       Impact factor: 5.157
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  8 in total

1.  Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis.

Authors:  Zinovia Kefalopoulou; Vassiliki Tzelepi; Vassiliki Zolota; Petros D Grivas; Christos Christopoulos; Haralabos Kalofonos; Theodoros Maraziotis; Georgia Sotiropoulou-Bonikou
Journal:  J Neurooncol       Date:  2011-07-07       Impact factor: 4.130

2.  Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.

Authors:  Sujit S Nair; Zhiyong Guo; Judith M Mueller; Shahriar Koochekpour; Yun Qiu; Rajeshwar Rao Tekmal; Roland Schüle; Hsing-Jien Kung; Rakesh Kumar; Ratna K Vadlamudi
Journal:  Mol Endocrinol       Date:  2006-12-27

Review 3.  PELP1: A novel therapeutic target for hormonal cancers.

Authors:  Dimple Chakravarty; Rajeshwar Rao Tekmal; Ratna K Vadlamudi
Journal:  IUBMB Life       Date:  2010-03       Impact factor: 3.885

4.  Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis.

Authors:  Vassiliki Tzelepi; Petros Grivas; Zinovia Kefalopoulou; Haralabos Kalofonos; John N Varakis; Georgia Sotiropoulou-Bonikou
Journal:  Virchows Arch       Date:  2008-12-02       Impact factor: 4.064

5.  Extranuclear coactivator signaling confers insensitivity to tamoxifen.

Authors:  Rakesh Kumar; Hao Zhang; Caroline Holm; Ratna K Vadlamudi; Goran Landberg; Suresh K Rayala
Journal:  Clin Cancer Res       Date:  2009-05-26       Impact factor: 12.531

6.  Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor.

Authors:  Rajib Rajhans; Sujit Nair; Alan H Holden; Rakesh Kumar; Rajeshwar Rao Tekmal; Ratna K Vadlamudi
Journal:  Cancer Res       Date:  2007-06-01       Impact factor: 12.701

Review 7.  Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.

Authors:  Ratna K Vadlamudi; Rakesh Kumar
Journal:  Nucl Recept Signal       Date:  2007-05-17

8.  Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth.

Authors:  Arianna De Luca; Paola Avena; Rosa Sirianni; Adele Chimento; Francesco Fallo; Catia Pilon; Ivan Casaburi; Vincenzo Pezzi
Journal:  Cells       Date:  2017-11-07       Impact factor: 6.600
  8 in total

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