| Literature DB >> 16824963 |
Adam W Anderson1, Rubina A Heptulla, Naomi Driesen, Daniel Flanagan, Philip A Goldberg, Timothy W Jones, Fran Rife, Hedy Sarofin, William Tamborlane, Robert Sherwin, John C Gore.
Abstract
Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 +/- 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28 +/- 12% (P < .05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.Entities:
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Year: 2006 PMID： 16824963 DOI： 10.1016/j.mri.2006.03.013
Source DB: PubMed Journal: Magn Reson Imaging ISSN： 0730-725X Impact factor: 2.546