Literature DB >> 16824759

Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.

Su Yeon Kim1, Yeon-Sook Lee, Taehee Kang, Sunghoon Kim, Jeewoo Lee.   

Abstract

We have performed virtual screening of a chemical database of 508,143 commercially available chemicals to search for new methionyl-tRNA synthetase (MetRS) inhibitors. In this study, potent lead compounds with a novel skeleton, including compound 27 with IC50 = 237 nM, were successfully identified as Escherichia coli MetRS inhibitors.

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Year:  2006        PMID： 16824759     DOI： 10.1016/j.bmcl.2006.06.057

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors:  Christopher S Francklyn; Patrick Mullen
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

2.  Novel hybrid virtual screening protocol based on molecular docking and structure-based pharmacophore for discovery of methionyl-tRNA synthetase inhibitors as antibacterial agents.

Authors:  Chi Liu; Gu He; Qinglin Jiang; Bo Han; Cheng Peng
Journal:  Int J Mol Sci       Date:  2013-07-09       Impact factor: 5.923

Review 3.  In silico discovery of aminoacyl-tRNA synthetase inhibitors.

Authors:  Yaxue Zhao; Qingqing Meng; Linquan Bai; Huchen Zhou
Journal:  Int J Mol Sci       Date:  2014-01-20       Impact factor: 5.923

4.  Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Authors:  Kayode K Ojo; Ranae M Ranade; Zhongsheng Zhang; David M Dranow; Janette B Myers; Ryan Choi; Steve Nakazawa Hewitt; Thomas E Edwards; Douglas R Davies; Donald Lorimer; Stephen M Boyle; Lynn K Barrett; Frederick S Buckner; Erkang Fan; Wesley C Van Voorhis
Journal:  PLoS One       Date:  2016-08-08       Impact factor: 3.240
  4 in total

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