| Literature DB >> 16824758 |
Kuppusamy Sujatha1, Pachaiyappan Shanmugam, Paramasivam T Perumal, Doraisamy Muralidharan, Melani Rajendran.
Abstract
A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.Entities:
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Year: 2006 PMID： 16824758 DOI： 10.1016/j.bmcl.2006.06.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823