David J Howard1, Valerie J Lund, William I Wei. 1. Institute of Laryngology and Otology, University College London, 330 Gray's Inn Road, London WC1X 8DA, United Kingdom.
Abstract
BACKGROUND: Craniofacial resection is the established "gold standard" for surgical treatment of tumors affecting the anterior skull base. METHODS: This study analyzed 308 patients (220 males, 88 females) who had undergone craniofacial resection for sinonasal neoplasia with up to 25-year follow-up. RESULTS: An overall actuarial survival of 65% at 5 years and 47% at 10 years was found for the cohort as a whole. For patients with malignant tumors, the 5-year actuarial survival was 59%, falling to 40% at 10 years. For patients with benign pathology, the actuarial survival was 92% at 5 years falling to 82% at 10 years. Statistical analysis again identified brain involvement, type of malignancy, and orbital involvement as the 3 most significant prognostic factors. CONCLUSION: Analysis of one of the largest single institution cohorts over a 25-year period provides a baseline against which other approaches such as an entirely endoscopic skull base resection must be judged. (c) 2006 Wiley Periodicals, Inc.
BACKGROUND: Craniofacial resection is the established "gold standard" for surgical treatment of tumors affecting the anterior skull base. METHODS: This study analyzed 308 patients (220 males, 88 females) who had undergone craniofacial resection for sinonasal neoplasia with up to 25-year follow-up. RESULTS: An overall actuarial survival of 65% at 5 years and 47% at 10 years was found for the cohort as a whole. For patients with malignant tumors, the 5-year actuarial survival was 59%, falling to 40% at 10 years. For patients with benign pathology, the actuarial survival was 92% at 5 years falling to 82% at 10 years. Statistical analysis again identified brain involvement, type of malignancy, and orbital involvement as the 3 most significant prognostic factors. CONCLUSION: Analysis of one of the largest single institution cohorts over a 25-year period provides a baseline against which other approaches such as an entirely endoscopic skull base resection must be judged. (c) 2006 Wiley Periodicals, Inc.
Authors: Shirley Y Su; Michael E Kupferman; Franco DeMonte; Nicholas B Levine; Shaan M Raza; Ehab Y Hanna Journal: Curr Oncol Rep Date: 2014-02 Impact factor: 5.075
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Authors: Matthew R Naunheim; Neerav Goyal; Matthew M Dedmon; Kyle J Chambers; Ahmad R Sedaghat; Benjamin S Bleier; Eric H Holbrook; William T Curry; Stacey T Gray; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2016-03-18