Literature DB >> 168233

Inhibitory effect of dietary iodine on the thyroid adenylate cyclase response to thyrotropin in the hypophysectomized rat.

B Rapoport, M N West, S H Ingbar.   

Abstract

In hypophysectomized rats given dietary regimens either rich or deficient in iodine, the increase in thyroid cyclic AMP concentration induced acutely by a single dose of TSH was significantly less in iodine-enriched than in iodine-deficient animals. Direct assays revealed that this difference was because the thyroid adenylate cyclase response to TSH was less in the iodine-enriched animals, phosphodiesterase activity being no different in the two groups. This effect may explain the inhibitory action of dietary iodine enrichment on diverse functional and anatomical responses of the thyroid to TSH.

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Year:  1975        PMID： 168233      PMCID： PMC436613          DOI： 10.1172/JCI108119

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  10 in total

1.  Regulation of the rat thyroid in short-term iodine deficiency.

Authors:  N S HALMI
Journal:  Endocrinology       Date:  1954-02       Impact factor: 4.736

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Adenosine 3',5'-cyclic phosphate phosphodiesterase from bovine thyroid: isolation and properties of a partially purified, soluble fraction.

Authors:  M Szabo; G Burke
Journal:  Biochim Biophys Acta       Date:  1972-09-19

4.  Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids.

Authors:  A L Steiner; A S Pagliara; L R Chase; D M Kipnis
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

5.  Thyroid hydrolysis of cyclic AMP as influenced by thyroid gland activity.

Authors:  C H Bastomsky; M Zakarija; J M McKenzie
Journal:  Biochim Biophys Acta       Date:  1971-02-23

Review 6.  The action of thyrotropin on thyroid metabolism.

Authors:  J E Dumont
Journal:  Vitam Horm       Date:  1971       Impact factor: 3.421

7.  A simple, sensitive method for the assay of adenyl cyclase.

Authors:  G Krishna; B Weiss; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1968-10       Impact factor: 4.030

8.  Autoregulation of the thyroid. Response to iodide excess and depletion.

Authors:  S H Ingbar
Journal:  Mayo Clin Proc       Date:  1972-11       Impact factor: 7.616

9.  Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate.

Authors:  A L Steiner; D M Kipnis; R Utiger; C Parker
Journal:  Proc Natl Acad Sci U S A       Date:  1969-09       Impact factor: 11.205

Review 10.  Iodide goiter and the pharmacologic effects of excess iodide.

Authors:  J Wolff
Journal:  Am J Med       Date:  1969-07       Impact factor: 4.965
  10 in total
  6 in total

1.  Correlated autoradiographic and ion-microscopic study of the role of iodine in the formation of "cold" follicles in young and old mice.

Authors:  C Mestdagh; M C Many; S Halpern; C Briançon; P Fragu; J F Denef
Journal:  Cell Tissue Res       Date:  1990-05       Impact factor: 5.249

Review 2.  Thyroid autoregulation.

Authors:  M A Pisarev
Journal:  J Endocrinol Invest       Date:  1985-10       Impact factor: 4.256

3.  Studies on the goiter endemia in Sicily.

Authors:  R Vigneri
Journal:  J Endocrinol Invest       Date:  1988-12       Impact factor: 4.256

Review 4.  Biochemistry of thyroid regulation under normal and abnormal conditions.

Authors:  M A Pisarev; D L Kleiman de Pisarev
Journal:  J Endocrinol Invest       Date:  1980 Jul-Sep       Impact factor: 4.256

5.  Reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. A clue to the pathogenesis of colloid goiters.

Authors:  H Gerber; H Studer; A Conti; H Engler; H Kohler; A Haeberli
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

6.  Aberrant Iodine Autoregulation Induces Hypothyroidism in a Mouse Strain in the Absence of Thyroid Autoimmunity.

Authors:  Sandra M McLachlan; Holly A Aliesky; Basil Rapoport
Journal:  J Endocr Soc       Date:  2017-11-29
  6 in total

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