PURPOSE: Dual inversion-recovery imaging (DIR) has been advocated for the diagnosis of cortical lesions in epileptic patients. The role of this sequence, however, is not established in tuberous sclerosis patients. METHODS: We studied prospectively the interest of DIR sequence in four well-documented consecutive tuberous sclerosis patients with focal epilepsy. RESULTS: In all patients, the cortical tubers appeared very bright on this sequence and were well outlined compared with high resolution T2 or FLAIR imaging. In two patients, one cortical tuber was missed on T2 weighted images due to signal intensity close to the CSF. These lesions were better depicted on DIR than on FLAIR. Three cortical lesions from two patients were visualized only on DIR. CONCLUSION: DIR helped to depict cortical tubers and may have a complementary role in the MRI evaluation of tuberous sclerosis patients. There is a need to compare sensitivity of T2, FLAIR and DIR with a larger population of patients with focal epilepsies.
PURPOSE: Dual inversion-recovery imaging (DIR) has been advocated for the diagnosis of cortical lesions in epilepticpatients. The role of this sequence, however, is not established in tuberous sclerosispatients. METHODS: We studied prospectively the interest of DIR sequence in four well-documented consecutive tuberous sclerosispatients with focal epilepsy. RESULTS: In all patients, the cortical tubers appeared very bright on this sequence and were well outlined compared with high resolution T2 or FLAIR imaging. In two patients, one cortical tuber was missed on T2 weighted images due to signal intensity close to the CSF. These lesions were better depicted on DIR than on FLAIR. Three cortical lesions from two patients were visualized only on DIR. CONCLUSION: DIR helped to depict cortical tubers and may have a complementary role in the MRI evaluation of tuberous sclerosispatients. There is a need to compare sensitivity of T2, FLAIR and DIR with a larger population of patients with focal epilepsies.
Authors: Bruno P Soares; Samuel G Porter; Amit M Saindane; Seena Dehkharghani; Nilesh K Desai Journal: Br J Radiol Date: 2015-11-03 Impact factor: 3.039
Authors: Martina Absinta; Maria A Rocca; Bruno Colombo; Massimiliano Copetti; Donatella De Feo; Andrea Falini; Giancarlo Comi; Massimo Filippi Journal: J Neurol Date: 2012-06-20 Impact factor: 4.849