Literature DB >> 16821763

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.

Ravi P Nargund1, Alison M Strack, Tung M Fong.   

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Year:  2006        PMID： 16821763     DOI： 10.1021/jm058241a

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  10 in total

1.  Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.

Authors:  Zhi-Qiang Wang; Ya-Xiong Tao
Journal:  Biochim Biophys Acta       Date:  2011-06-30

2.  Structural insights into ligand recognition and activation of the melanocortin-4 receptor.

Authors:  Huibing Zhang; Li-Nan Chen; Dehua Yang; Chunyou Mao; Qingya Shen; Wenbo Feng; Dan-Dan Shen; Antao Dai; Shanshan Xie; Yan Zhou; Jiao Qin; Jin-Peng Sun; Daniel H Scharf; Tingjun Hou; Tianhua Zhou; Ming-Wei Wang; Yan Zhang
Journal:  Cell Res       Date:  2021-08-25       Impact factor: 25.617

3.  Inhibition of the central melanocortin system decreases brown adipose tissue activity.

Authors:  Sander Kooijman; Mariëtte R Boon; Edwin T Parlevliet; Janine J Geerling; Vera van de Pol; Johannes A Romijn; Louis M Havekes; Illiana Meurs; Patrick C N Rensen
Journal:  J Lipid Res       Date:  2014-07-12       Impact factor: 5.922

4.  Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors.

Authors:  Anamika Singh; Johannes Kast; Marvin L S Dirain; Huisuo Huang; Carrie Haskell-Luevano
Journal:  ACS Chem Neurosci       Date:  2015-12-24       Impact factor: 4.418

5.  Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach.

Authors:  Bethany A Falls; Yan Zhang
Journal:  ACS Chem Neurosci       Date:  2018-08-13       Impact factor: 4.418

6.  Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.

Authors:  Anil K Malhotra; Christoph U Correll; Nabilah I Chowdhury; Daniel J Müller; Peter K Gregersen; Annette T Lee; Arun K Tiwari; John M Kane; W Wolfgang Fleischhacker; Rene S Kahn; Roel A Ophoff; Herbert Y Meltzer; Todd Lencz; James L Kennedy
Journal:  Arch Gen Psychiatry       Date:  2012-09

7.  The central melanocortin system directly controls peripheral lipid metabolism.

Authors:  Ruben Nogueiras; Petra Wiedmer; Diego Perez-Tilve; Christelle Veyrat-Durebex; Julia M Keogh; Gregory M Sutton; Paul T Pfluger; Tamara R Castaneda; Susanne Neschen; Susanna M Hofmann; Philip N Howles; Donald A Morgan; Stephen C Benoit; Ildiko Szanto; Brigitte Schrott; Annette Schürmann; Hans-Georg Joost; Craig Hammond; David Y Hui; Stephen C Woods; Kamal Rahmouni; Andrew A Butler; I Sadaf Farooqi; Stephen O'Rahilly; Françoise Rohner-Jeanrenaud; Matthias H Tschöp
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808

Review 8.  Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases.

Authors:  Alexander O Shpakov; Kira V Derkach; Lev M Berstein
Journal:  Future Sci OA       Date:  2015-11-01

9.  New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis.

Authors:  Juan A Orellana; Waldo Cerpa; Maria F Carvajal; José M Lerma-Cabrera; Eduardo Karahanian; Cesar Osorio-Fuentealba; Rodrigo A Quintanilla
Journal:  Front Cell Neurosci       Date:  2017-04-05       Impact factor: 5.505

Review 10.  The functional state of hormone-sensitive adenylyl cyclase signaling system in diabetes mellitus.

Authors:  Alexander O Shpakov; Kira V Derkach
Journal:  J Signal Transduct       Date:  2013-09-28
  10 in total

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