Literature DB >> 16820298

Apolipoprotein E structure: insights into function.

Danny M Hatters1, Clare A Peters-Libeu, Karl H Weisgraber.   

Abstract

Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through its interaction with members of the low-density lipoprotein receptor family, apoE has a key role in lipid transport both in the plasma and in the central nervous system. Its three common structural isoforms differentially affect the risk of developing atherosclerosis and neurodegenerative disorders, including Alzheimer's disease. Because the function of apoE is dictated by its structure, understanding the structural properties of apoE and its isoforms is required both to determine its role in disease and for the development of therapeutic strategies.

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Year:  2006        PMID： 16820298     DOI： 10.1016/j.tibs.2006.06.008

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  215 in total

1.  The association−dissociation behavior of the ApoE proteins: kinetic and equilibrium studies.

Authors:  Kanchan Garai; Carl Frieden
Journal:  Biochemistry       Date:  2010-11-09       Impact factor: 3.162

2.  Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.

Authors:  Chiharu Mizuguchi; Mami Hata; Padmaja Dhanasekaran; Margaret Nickel; Michael C Phillips; Sissel Lund-Katz; Hiroyuki Saito
Journal:  Biochemistry       Date:  2012-07-03       Impact factor: 3.162

3.  Structure of saposin A lipoprotein discs.

Authors:  Konstantin Popovic; John Holyoake; Régis Pomès; Gilbert G Privé
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-02       Impact factor: 11.205

4.  The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3.

Authors:  Gursharan K Bains; Sea H Kim; Eric J Sorin; Vasanthy Narayanaswami
Journal:  Biochemistry       Date:  2012-07-26       Impact factor: 3.162

5.  Characterization of the apoLp-III/LPS complex: insight into the mode of binding interaction.

Authors:  Merve Oztug; Daisy Martinon; Paul M M Weers
Journal:  Biochemistry       Date:  2012-07-25       Impact factor: 3.162

6.  Age-related decreases in SYN levels associated with increases in MAP-2, apoE, and GFAP levels in the rhesus macaque prefrontal cortex and hippocampus.

Authors:  Gwendolen E Haley; Steven G Kohama; Henryk F Urbanski; Jacob Raber
Journal:  Age (Dordr)       Date:  2010-04-13

7.  Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry.

Authors:  Tuyen N Tran; Malathi G Kosaraju; Shiori Tamamizu-Kato; Olayemi Akintunde; Ying Zheng; John K Bielicki; Kent Pinkerton; Koji Uchida; Yuan Yu Lee; Vasanthy Narayanaswami
Journal:  Biochemistry       Date:  2014-01-08       Impact factor: 3.162

8.  Transfer of C-terminal residues of human apolipoprotein A-I to insect apolipophorin III creates a two-domain chimeric protein with enhanced lipid binding activity.

Authors:  James V C Horn; Rachel A Ellena; Jesse J Tran; Wendy H J Beck; Vasanthy Narayanaswami; Paul M M Weers
Journal:  Biochim Biophys Acta Biomembr       Date:  2017-04-21       Impact factor: 3.747

Review 9.  ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

Authors:  Takahisa Kanekiyo; Huaxi Xu; Guojun Bu
Journal:  Neuron       Date:  2014-02-19       Impact factor: 17.173

10.  Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.

Authors:  Irina N Gorshkova; Kyriakos E Kypreos; Donald L Gantz; Vassilis I Zannis; David Atkinson
Journal:  Biochemistry       Date:  2008-11-25       Impact factor: 3.162
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