| Literature DB >> 16820216 |
Mathula Thangarajh1, Thomas Masterman, Lars Helgeland, Uros Rot, Malin V Jonsson, Geir Egil Eide, Ritva Pirskanen, Jan Hillert, Roland Jonsson.
Abstract
The accumulation of B cells in the thymus is a common feature of myasthenia gravis (MG). To understand whether factors enhancing B-cell survival are increased in MG, we studied the expression of APRIL, BAFF and three of their receptors in the thymus. In hyperplastic thymi, macrophages expressed APRIL and BAFF, and germinal-center B cells, BAFF-R. CD138-positive plasma cells were abundant in MG thymi. By contrast, BCMA-positive plasma cells were scarce. The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B-cell survival.Entities:
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Year: 2006 PMID： 16820216 DOI： 10.1016/j.jneuroim.2006.05.023
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478