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Literature DB >> 16819551

Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates.

Patrick Freund¹, Eric Schmidlin, Thierry Wannier, Jocelyne Bloch, Anis Mir, Martin E Schwab, Eric M Rouiller.

Abstract

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.

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Year: 2006 PMID： 16819551 DOI： 10.1038/nm1436

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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Cited

99 in total

1. Recovery from chronic spinal cord contusion after Nogo receptor intervention.

Authors: Xingxing Wang; Philip Duffy; Aaron W McGee; Omar Hasan; Grahame Gould; Nathan Tu; Noam Y Harel; Yiyun Huang; Richard E Carson; David Weinzimmer; Jim Ropchan; Larry I Benowitz; William B J Cafferty; Stephen M Strittmatter
Journal: Ann Neurol Date: 2011-11 Impact factor: 10.422

2. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

Authors: Farida Hellal; Andres Hurtado; Jörg Ruschel; Kevin C Flynn; Claudia J Laskowski; Martina Umlauf; Lukas C Kapitein; Dinara Strikis; Vance Lemmon; John Bixby; Casper C Hoogenraad; Frank Bradke
Journal: Science Date: 2011-01-27 Impact factor: 47.728

3. Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury.

Authors: Ali Ertürk; Christoph P Mauch; Farida Hellal; Friedrich Förstner; Tara Keck; Klaus Becker; Nina Jährling; Heinz Steffens; Melanie Richter; Mark Hübener; Edgar Kramer; Frank Kirchhoff; Hans Ulrich Dodt; Frank Bradke
Journal: Nat Med Date: 2011-12-25 Impact factor: 53.440

Review 4. Neural regeneration: lessons from regenerating and non-regenerating systems.

Authors: Leonardo M R Ferreira; Elisa M Floriddia; Giorgia Quadrato; Simone Di Giovanni
Journal: Mol Neurobiol Date: 2012-06-21 Impact factor: 5.590

5. Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

Authors: Grégoire Courtine; Mary Bartlett Bunge; James W Fawcett; Robert G Grossman; Jon H Kaas; Roger Lemon; Irin Maier; John Martin; Randolph J Nudo; Almudena Ramon-Cueto; Eric M Rouiller; Lisa Schnell; Thierry Wannier; Martin E Schwab; V Reggie Edgerton
Journal: Nat Med Date: 2007-05 Impact factor: 53.440

Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates.

1. Recovery from chronic spinal cord contusion after Nogo receptor intervention.

2. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

3. Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury.

Review 4. Neural regeneration: lessons from regenerating and non-regenerating systems.

5. Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

6. Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system.

Review 7. Regenerative therapies for central nervous system diseases: a biomaterials approach.

8. Role of Nogo-A in neuronal survival in the reperfused ischemic brain.

9. Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke.

Review 10. A systematic review of directly applied biologic therapies for acute spinal cord injury.