Literature DB >> 16819205

Biotransformation of physalin H and leishmanicidal activity of its transformed products.

Muhammad Iqbal Choudhary1, Sammer Yousuf, Syed Adnan Ali Shah, Shakil Ahmed.   

Abstract

The transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC50 values in the range of 6.03-13.80 microM.

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Year:  2006        PMID： 16819205     DOI： 10.1248/cpb.54.927

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

Review 1.  Therapeutic Applications of Physalins: Powerful Natural Weapons.

Authors:  Cássio Santana Meira; José Waldson Capinan Soares; Bruna Padilha Zurita Claro Dos Reis; Luciano Vasconcellos Pacheco; Ivanilson Pimenta Santos; Dahara Keyse Carvalho Silva; Julia Costa de Lacerda; Sérgio Ricardo Teixeira Daltro; Elisalva Teixeira Guimarães; Milena Botelho Pereira Soares
Journal:  Front Pharmacol       Date:  2022-04-05       Impact factor: 5.988

2.  New Anti-Inflammatory Metabolites by Microbial Transformation of Medrysone.

Authors:  Saira Bano; Atia-Tul- Wahab; Sammer Yousuf; Almas Jabeen; Mohammad Ahmed Mesaik; Atta-Ur- Rahman; M Iqbal Choudhary
Journal:  PLoS One       Date:  2016-04-22       Impact factor: 3.240

3.  Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors.

Authors:  Ruizhi Men; Ning Li; Chihong Ding; Yingzhan Tang; Yachao Xing; Wanjing Ding; Zhongjun Ma
Journal:  Pharmacogn Mag       Date:  2016-05-11       Impact factor: 1.085

4.  Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities.

Authors:  Cheng-Peng Sun; Chong-Yue Qiu; Feng Zhao; Ning Kang; Li-Xia Chen; Feng Qiu
Journal:  Sci Rep       Date:  2017-06-22       Impact factor: 4.379

5.  Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites.

Authors:  Mahwish Siddiqui; Malik Shoaib Ahmad; Atia-Tul- Wahab; Sammer Yousuf; Narjis Fatima; Nimra Naveed Shaikh; Atta-Ur- Rahman; M Iqbal Choudhary
Journal:  PLoS One       Date:  2017-02-24       Impact factor: 3.240

Review 6.  Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.

Authors:  Syed Adnan Ali Shah; Huey Ling Tan; Sadia Sultan; Muhammad Afifi Bin Mohd Faridz; Mohamad Azlan Bin Mohd Shah; Sharifah Nurfazilah; Munawar Hussain
Journal:  Int J Mol Sci       Date:  2014-07-07       Impact factor: 5.923

Review 7.  Microbial Biotransformation to Obtain New Antifungals.

Authors:  Luiz F Bianchini; Maria F C Arruda; Sergio R Vieira; Patrícia M S Campelo; Ana M T Grégio; Edvaldo A R Rosa
Journal:  Front Microbiol       Date:  2015-12-24       Impact factor: 5.640
  7 in total

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