| Literature DB >> 16819196 |
Ibrahim Iliya1, Yukihiro Akao, Kenji Matsumoto, Yoshihito Nakagawa, Ali Zulfiqar, Tetsuro Ito, Masayoshi Oyama, Hiroko Murata, Toshiyuki Tanaka, Yoshinori Nozawa, Munekazu Iinuma.
Abstract
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC(50) of 10.0 microM and 12.2 microM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.Entities:
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Year: 2006 PMID： 16819196 DOI： 10.1248/bpb.29.1490
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233