| Literature DB >> 1681885 |
K Sakata1, T T Kwok, B J Murphy, K R Laderoute, G R Gordon, R M Sutherland.
Abstract
In this report, we investigate several examples of hypoxia-induced drug resistance and compare them with P-glycoprotein associated multidrug resistance (MDR). EMT6/Ro cells exposed to drugs in air immediately after hypoxic treatment developed resistance to adriamycin, 5-fluorouracil, and actinomycin D. However, these cells did not develop resistance to colchicine, vincristine or cisplatin. When the cells were returned to a normal oxygen environment, they lost resistance. There was no correlation between the content of adriamycin and the development of adriamycin resistance induced by hypoxia. There was no difference between the efflux of adriamycin from aerobic cells and that from hypoxia-treated cells. The mRNA for P-glycoprotein was not detected in the hypoxia-treated cells. These results suggest that hypoxia-induced drug resistance is different from P-glycoprotein associated multidrug resistance.Entities:
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Year: 1991 PMID： 1681885 PMCID： PMC1977469 DOI： 10.1038/bjc.1991.405
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640