Literature DB >> 16818384

RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing.

Fatiha Boukhtouche1, Mohamed Doulazmi, Florence Frederic, Isabelle Dusart, Bernard Brugg, Jean Mariani.   

Abstract

RORalpha (Retinoid-related Orphan Receptor) is a transcription factor belonging to the superfamily of nuclear receptors. The spontaneous staggerer (sg) mutation, which consists of a deletion in the Rora gene, has been shown to cause the loss of function of the RORalpha protein. The total loss of RORalpha expression leads to cerebellar developmental defects, particularly to a dramatic decreased survival of Purkinje cells and an early block in the differentiation process. This review focuses on recent studies which position RORalpha as a pivotal factor controlling Purkinje cell survival and differentiation, from development to ageing.

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Year:  2006        PMID： 16818384     DOI： 10.1080/14734220600750184

Source DB:  PubMed          Journal:  Cerebellum        ISSN： 1473-4222            Impact factor:   3.648


  84 in total

Review 1.  A rhythmic Ror.

Authors:  Patrick Emery; Steven M Reppert
Journal:  Neuron       Date:  2004-08-19       Impact factor: 17.173

2.  Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences.

Authors:  M Becker-André; E André; J F DeLamarter
Journal:  Biochem Biophys Res Commun       Date:  1993-08-16       Impact factor: 3.575

3.  A qualitative and quantitative light microscopic study of the inferior olivary complex in the adult staggerer mutant mouse.

Authors:  G J Blatt; L M Eisenman
Journal:  J Neurogenet       Date:  1985-02       Impact factor: 1.250

4.  Postnatal cerebellar cells from staggerer mutant mice express embryonic cell surface characteristic.

Authors:  M E Hatten; A Messer
Journal:  Nature       Date:  1978-11-30       Impact factor: 49.962

5.  The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response.

Authors:  P Delerive; D Monté; G Dubois; F Trottein; J Fruchart-Najib; J Mariani; J C Fruchart; B Staels
Journal:  EMBO Rep       Date:  2001-01       Impact factor: 8.807

6.  A role for both wild-type and expanded ataxin-7 in transcriptional regulation.

Authors:  Anna-Lena Ström; Lars Forsgren; Monica Holmberg
Journal:  Neurobiol Dis       Date:  2005-06-03       Impact factor: 5.996

7.  The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1.

Authors:  Makoto Akashi; Toru Takumi
Journal:  Nat Struct Mol Biol       Date:  2005-04-10       Impact factor: 15.369

Review 8.  ROR alpha in genetic control of cerebellum development: 50 staggering years.

Authors:  David A Gold; Peter M Gent; Bruce A Hamilton
Journal:  Brain Res       Date:  2006-01-19       Impact factor: 3.252

9.  Early postnatal Purkinje cells from staggerer mice undergo aberrant development in vitro with characteristic morphologic and gene expression abnormalities.

Authors:  L Thomas Shirley; Anne Messer
Journal:  Brain Res Dev Brain Res       Date:  2004-09-17

10.  The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1.

Authors:  Caroline Chauvet; Brigitte Bois-Joyeux; Edurne Berra; Jacques Pouyssegur; Jean-Louis Danan
Journal:  Biochem J       Date:  2004-11-15       Impact factor: 3.857
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  22 in total

1.  Hormonal regulation of cerebellar development and plasticity.

Authors:  Noriyuki Koibuchi
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

Review 2.  Maintenance of postmitotic neuronal cell identity.

Authors:  Evan S Deneris; Oliver Hobert
Journal:  Nat Neurosci       Date:  2014-06-15       Impact factor: 24.884

3.  Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.

Authors:  AnhThu Nguyen; Tibor A Rauch; Gerd P Pfeifer; Valerie W Hu
Journal:  FASEB J       Date:  2010-04-07       Impact factor: 5.191

4.  Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.

Authors:  Kazuhiro Mitsumura; Nobutake Hosoi; Nobuhiko Furuya; Hirokazu Hirai
Journal:  J Physiol       Date:  2011-05-09       Impact factor: 5.182

5.  Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.

Authors:  Hong Soon Kang; Kyoko Okamoto; Yukimasa Takeda; Ju Youn Beak; Kevin Gerrish; Carl D Bortner; Laura M DeGraff; Taira Wada; Wen Xie; Anton M Jetten
Journal:  Physiol Genomics       Date:  2011-05-03       Impact factor: 3.107

6.  Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.

Authors:  Shashwath A Meda; Gualberto Ruaño; Andreas Windemuth; Kasey O'Neil; Clifton Berwise; Sabra M Dunn; Leah E Boccaccio; Balaji Narayanan; Mohan Kocherla; Emma Sprooten; Matcheri S Keshavan; Carol A Tamminga; John A Sweeney; Brett A Clementz; Vince D Calhoun; Godfrey D Pearlson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-28       Impact factor: 11.205

7.  Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα.

Authors:  Fatiha Boukhtouche; Bernard Brugg; Rosine Wehrlé; Brigitte Bois-Joyeux; Jean-Louis Danan; Isabelle Dusart; Jean Mariani
Journal:  Neural Dev       Date:  2010-07-27       Impact factor: 3.842

8.  The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.

Authors:  Nobumichi Ohoka; Shogo Kato; Yu Takahashi; Hidetoshi Hayashi; Ryuichiro Sato
Journal:  Mol Endocrinol       Date:  2009-03-26

9.  Ataxia telangiectasia alters the ApoB and reelin pathway.

Authors:  Júlia Canet-Pons; Ralf Schubert; Ruth Pia Duecker; Roland Schrewe; Sandra Wölke; Matthias Kieslich; Martina Schnölzer; Andreas Chiocchetti; Georg Auburger; Stefan Zielen; Uwe Warnken
Journal:  Neurogenetics       Date:  2018-10-21       Impact factor: 2.660

10.  Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.

Authors:  Sonja Janmaat; Yvette Akwa; Mohamed Doulazmi; Joëlle Bakouche; Vanessa Gautheron; Philippe Liere; Bernard Eychenne; Antoine Pianos; Paul Luiten; Ton Groothuis; Etienne-Emile Baulieu; Jean Mariani; Rachel M Sherrard; Florence Frédéric
Journal:  Age (Dordr)       Date:  2011-01-11
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