| Literature DB >> 16818172 |
Abstract
Neurofibromatosis types 1 and 2 (NF1 and NF2) are autosomal dominant phakomatoses. The NF1 and NF2 genes encode for neurofibromin and merlin, respectively. These 2 functionally unrelated proteins both act as tumor suppressor genes, possibly through modulation of the RAS/RAC oncogenic pathways. Improved understanding of the mechanisms by which these tumor suppressors act may allow for medical therapies for neurofibromatosis and may offer insights for cancer therapeutics.Entities:
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Year: 2006 PMID： 16818172 DOI： 10.1016/j.spen.2006.01.007
Source DB: PubMed Journal: Semin Pediatr Neurol ISSN： 1071-9091 Impact factor: 1.636