Literature DB >> 16816134

Retinoblastoma tumor suppressor: where cancer meets the cell cycle.

Erik S Knudsen1, Karen E Knudsen.   

Abstract

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Entities:  

Mesh：

Year:  2006        PMID： 16816134     DOI： 10.1177/153537020623100713

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  42 in total

1.  Association of RNF43 with cell cycle proteins involved in p53 pathway.

Authors:  Haiyang Xie; Chunyang Xing; Guoqiang Cao; Bajin Wei; Xiao Xu; Penghong Song; Leiming Chen; Hai Chen; Shengyong Yin; Lin Zhou; Shusen Zheng
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

Review 2.  Cancer models in Caenorhabditis elegans.

Authors:  Natalia V Kirienko; Kumaran Mani; David S Fay
Journal:  Dev Dyn       Date:  2010-05       Impact factor: 3.780

3.  p27(KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouse.

Authors:  Xuekun Li; Xiaobing Tang; Beata Jablonska; Adan Aguirre; Vittorio Gallo; Marla B Luskin
Journal:  J Neurosci       Date:  2009-03-04       Impact factor: 6.167

4.  Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.

Authors:  Christopher A Reed; Christopher N Mayhew; A Kathleen McClendon; Erik S Knudsen
Journal:  J Biol Chem       Date:  2009-11-02       Impact factor: 5.157

5.  Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.

Authors:  David S Simpson; Nicole A Mason-Richie; Caitlin A Gettler; Kathryn A Wikenheiser-Brokamp
Journal:  Cancer Res       Date:  2009-11-03       Impact factor: 12.701

6.  Clinicopathologic Features Associated With Human Papillomavirus/p16 in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal.

Authors:  Van K Morris; Asif Rashid; Miguel Rodriguez-Bigas; Prajnan Das; George Chang; Aki Ohinata; Jane Rogers; Christopher Crane; Robert A Wolff; Cathy Eng
Journal:  Oncologist       Date:  2015-09-17

7.  A suppressor screen in chlamydomonas identifies novel components of the retinoblastoma tumor suppressor pathway.

Authors:  Su-Chiung Fang; James G Umen
Journal:  Genetics       Date:  2008-03       Impact factor: 4.562

Review 8.  The rb pathway and cancer therapeutics.

Authors:  W Du; J S Searle
Journal:  Curr Drug Targets       Date:  2009-07       Impact factor: 3.465

9.  RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1.

Authors:  C A Reed; C N Mayhew; A K McClendon; X Yang; A Witkiewicz; E S Knudsen
Journal:  Oncogene       Date:  2009-10-19       Impact factor: 9.867

10.  Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome.

Authors:  E K A Millar; J L Dean; C M McNeil; S A O'Toole; S M Henshall; T Tran; J Lin; A Quong; C E S Comstock; A Witkiewicz; E A Musgrove; H Rui; L Lemarchand; V W Setiawan; C A Haiman; K E Knudsen; R L Sutherland; E S Knudsen
Journal:  Oncogene       Date:  2009-03-16       Impact factor: 9.867
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