Literature DB >> 1681588

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.

P Salgame1, J S Abrams, C Clayberger, H Goldstein, J Convit, R L Modlin, B R Bloom.   

Abstract

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

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Year:  1991        PMID： 1681588     DOI： 10.1126/science.1681588

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  225 in total

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Review 5.  Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis.

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7.  On cell signalling mechanism of Mycobacterium leprae soluble antigen (MLSA) in Jurkat T cells.

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Authors:  P Life; J F Gauchat; V Schnuriger; S Estoppey; G Mazzei; A Durandy; A Fischer; J Y Bonnefoy
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9.  Immunological changes of T helper cells in flow cytometer-sorted CD4+ T cells from patients with Hashimoto's thyroiditis.

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10.  Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses.

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