OBJECTIVE: High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding. METHODS: Twenty spontaneously hypertensive rats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes (copper/zinc superoxide dismutase and glutathione peroxidase) were also investigated in hepatic tissue. RESULTS: Fructose-fed rats showed blood pressure values similar to that of control rats but had increased glycemia and insulinemia. The antioxidant capacity in the blood of the fructose-fed group represented by copper/zinc superoxide dismutase and glutathione peroxidase activities and ascorbic acid was lower. However, the fructose diet enhanced the total antioxidant capacity of liver correlated with increased antioxidant enzyme activities and retinol concentrations. Gutathione peroxidase mRNA expression was decreased in livers of spontaneously hypertensive rats fed the fructose diet. CONCLUSION: Fructose feeding negatively affects antioxidant capacity in the blood of hypertensive rats but improves this capacity in the liver.
OBJECTIVE: High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding. METHODS: Twenty spontaneously hypertensiverats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes (copper/zinc superoxide dismutase and glutathione peroxidase) were also investigated in hepatic tissue. RESULTS:Fructose-fed rats showed blood pressure values similar to that of control rats but had increased glycemia and insulinemia. The antioxidant capacity in the blood of the fructose-fed group represented by copper/zinc superoxide dismutase and glutathione peroxidase activities and ascorbic acid was lower. However, the fructose diet enhanced the total antioxidant capacity of liver correlated with increased antioxidant enzyme activities and retinol concentrations. Gutathione peroxidase mRNA expression was decreased in livers of spontaneously hypertensiverats fed the fructose diet. CONCLUSION:Fructose feeding negatively affects antioxidant capacity in the blood of hypertensiverats but improves this capacity in the liver.
Authors: Leandro Sommese; Carlos A Valverde; Paula Blanco; María Cecilia Castro; Omar Velez Rueda; Marcia Kaetzel; John Dedman; Mark E Anderson; Alicia Mattiazzi; Julieta Palomeque Journal: Int J Cardiol Date: 2015-09-25 Impact factor: 4.164
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Authors: Hala O El Mesallamy; Ebtehal El-Demerdash; Lamiaa N Hammad; Hekmat M El Magdoub Journal: Diabetol Metab Syndr Date: 2010-06-30 Impact factor: 3.320
Authors: Alejandro Rebolledo; Oscar R Rebolledo; Carlos A Marra; María E García; Ana R Roldán Palomo; Laura Rimorini; Juan J Gagliardino Journal: Cardiovasc Diabetol Date: 2010-10-21 Impact factor: 9.951
Authors: Ana C Ghezzi; Lucieli T Cambri; Carla Ribeiro; José D Botezelli; Maria A R Mello Journal: Lipids Health Dis Date: 2011-01-11 Impact factor: 3.876