OBJECTIVE: To assess the relationship between pre-operative serum urea and electrolyte concentrations and mortality in patients with hip fractures requiring surgery. METHODS: A prospective observational study of 2963 consecutive patients admitted to a single trauma unit with a hip fracture, treated operatively. RESULTS: The 30-day mortality for patients with low and normal urea concentrations was 6.9%. The 30-day mortality for patients with raised urea concentrations was almost double (11.5%). A raised admission serum urea concentration was an independent predictor for mortality at 30 days, 90 days, 1 year and 2 years. Mortality was significantly increased in patients admitted with: raised or low serum sodium, raised serum potassium and raised serum creatinine. CONCLUSION: Mortality is high following hip fracture. Patients admitted with a raised serum urea are at increased risk of death at all time intervals analysed up to and including 2 years. This group of patients may require a separate care pathway that provides more intensive management of fluid and electrolyte balance.
OBJECTIVE: To assess the relationship between pre-operative serum urea and electrolyte concentrations and mortality in patients with hip fractures requiring surgery. METHODS: A prospective observational study of 2963 consecutive patients admitted to a single trauma unit with a hip fracture, treated operatively. RESULTS: The 30-day mortality for patients with low and normal urea concentrations was 6.9%. The 30-day mortality for patients with raised urea concentrations was almost double (11.5%). A raised admission serum urea concentration was an independent predictor for mortality at 30 days, 90 days, 1 year and 2 years. Mortality was significantly increased in patients admitted with: raised or low serum sodium, raised serum potassium and raised serum creatinine. CONCLUSION: Mortality is high following hip fracture. Patients admitted with a raised serum urea are at increased risk of death at all time intervals analysed up to and including 2 years. This group of patients may require a separate care pathway that provides more intensive management of fluid and electrolyte balance.
Authors: Tatyana Vikulina; Xian Fan; Masayoshi Yamaguchi; Susanne Roser-Page; Majd Zayzafoon; David M Guidot; Ighovwerha Ofotokun; M Neale Weitzmann Journal: Proc Natl Acad Sci U S A Date: 2010-07-19 Impact factor: 11.205
Authors: Benjamin Voss; Alexander Kurdi; Alexander Skopec; Jasmine Saleh; Mouhanad M El-Othmani; Joseph M Lane; William M Mihalko; Khaled J Saleh Journal: J Nat Sci Date: 2015-02-01
Authors: Francesco Grassi; Abdul Malik Tyagi; John W Calvert; Laura Gambari; Lindsey D Walker; Mingcan Yu; Jerid Robinson; Jau-Yi Li; Gina Lisignoli; Chiara Vaccaro; Jonathan Adams; Roberto Pacifici Journal: J Bone Miner Res Date: 2015-12-23 Impact factor: 6.741
Authors: George A Macheras; Konstantinos Kateros; Stefanos D Koutsostathis; Stamatios A Papadakis; Eleftherios Tsiridis Journal: Clin Orthop Relat Res Date: 2013-12 Impact factor: 4.176