| Literature DB >> 16815153 |
Bernhard Homey1, Martin Steinhoff, Thomas Ruzicka, Donald Y M Leung.
Abstract
Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.Entities:
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Year: 2006 PMID： 16815153 DOI： 10.1016/j.jaci.2006.03.047
Source DB: PubMed Journal: J Allergy Clin Immunol ISSN： 0091-6749 Impact factor: 10.793