| Literature DB >> 16814724 |
Abstract
In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.Entities:
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Year: 2006 PMID： 16814724 DOI： 10.1016/j.cmet.2006.06.004
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287