Comparison of antitumor activities in tumor xenograft treatment.

To compare treatment effects with antitumor therapies, we proposed an intuitive approach to compare the antitumor effects of two different antitumor treatments by investigating tumor volumes which were measured in a given period of time. The approach is, in essence, a comparison of two unknown functions. The implementation of the approach is simple and straightforward. The approach is applied to analyze a real xenograft study of a new antitumor agent, irofulven, combined with irinotecan.