OBJECTIVE: The purpose of this study was to determine if maternal serum concentrations of placenta growth factor (PlGF) and soluble Fms-like tyrosine kinase 1 receptor (s-Flt1) are more abnormal in patients with severe preeclampsia compared with mild preeclampsia. STUDY DESIGN: Serum samples were collected from 32 control patients and 80 patients with mild or severe preeclampsia. PlGF and s-Flt1 concentrations were quantitated by enzyme-linked immunosorbent assay (ELISA). Results are expressed as median (Q1-Q3) unless stated otherwise. After normalization, serum markers were compared using one-way analysis of covariance (ANCOVA). RESULTS: Patients with preeclampsia had decreased levels of PlGF (75.1 +/- 14 vs 391 +/- 54 pg/mL, P < .0001) and elevated s-Flt1 concentration (1081 +/- 108 vs 100.1 +/- 26.9 pg/mL, P < .0001) compared with the respective controls (mean +/- SEM). PlGF concentration was lower in patients with mild preeclampsia compared with severe, respectively (67 pg/mL [39-158] vs 24 pg/mL [4-57], P < .02). s-Flt1 was not different between mild and severe preeclampsia (674 pg/mL [211-1297] vs 1015 pg/mL [731-1948], P = .08). CONCLUSION: PlGF and s-Flt1 serum levels are abnormal in patients with preeclampsia compared with controls, but only PlGF is more abnormal in severe preeclampsia compared with mild preeclampsia.
OBJECTIVE: The purpose of this study was to determine if maternal serum concentrations of placenta growth factor (PlGF) and soluble Fms-like tyrosine kinase 1 receptor (s-Flt1) are more abnormal in patients with severe preeclampsia compared with mild preeclampsia. STUDY DESIGN: Serum samples were collected from 32 control patients and 80 patients with mild or severe preeclampsia. PlGF and s-Flt1 concentrations were quantitated by enzyme-linked immunosorbent assay (ELISA). Results are expressed as median (Q1-Q3) unless stated otherwise. After normalization, serum markers were compared using one-way analysis of covariance (ANCOVA). RESULTS:Patients with preeclampsia had decreased levels of PlGF (75.1 +/- 14 vs 391 +/- 54 pg/mL, P < .0001) and elevated s-Flt1 concentration (1081 +/- 108 vs 100.1 +/- 26.9 pg/mL, P < .0001) compared with the respective controls (mean +/- SEM). PlGF concentration was lower in patients with mild preeclampsia compared with severe, respectively (67 pg/mL [39-158] vs 24 pg/mL [4-57], P < .02). s-Flt1 was not different between mild and severe preeclampsia (674 pg/mL [211-1297] vs 1015 pg/mL [731-1948], P = .08). CONCLUSION:PlGF and s-Flt1 serum levels are abnormal in patients with preeclampsia compared with controls, but only PlGF is more abnormal in severe preeclampsia compared with mild preeclampsia.
Authors: Roberto Romero; Tinnakorn Chaiworapongsa; Offer Erez; Adi L Tarca; Maria Teresa Gervasi; Juan Pedro Kusanovic; Pooja Mittal; Giovanna Ogge; Edi Vaisbuch; Shali Mazaki-Tovi; Zhong Dong; Sun Kwon Kim; Lami Yeo; Sonia S Hassan Journal: J Matern Fetal Neonatal Med Date: 2010-05-12
Authors: Elena R Rivers; Anthony J Horton; Angela F Hawk; Elizabeth G Favre; Katherine M Senf; Paul J Nietert; Eugene Y Chang; Ann C Foley; Christopher J Robinson; Kyu-Ho Lee Journal: Hypertens Pregnancy Date: 2014-07-02 Impact factor: 2.108
Authors: Eleazar Soto; Roberto Romero; Karina Richani; Jimmy Espinoza; Tinnakorn Chaiworapongsa; Jyh Kae Nien; Sam S Edwin; Yeon Mee Kim; Joon Seok Hong; Luis F Goncalves; Lami Yeo; Moshe Mazor; Sonia S Hassan; Juan Pedro Kusanovic Journal: J Matern Fetal Neonatal Med Date: 2010-07