Literature DB >> 1681217

Is postoperative delirium related to reduced plasma tryptophan?

R C van der Mast1, D Fekkes, P Moleman, L Pepplinkhuizen.   

Abstract

The cause of postoperative delirium is unknown. In 7 patients with postcardiotomy delirium (6 men, 1 woman; mean age 67 years), we observed a plasma concentration of tryptophan and a plasma tryptophan ratio significantly lower than in 8 non-delirious postoperative control patients. We suggest that the mental symptoms of postcardiotomy delirium are the consequence of a reduced cerebral tryptophan availability due to a catabolic state.

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Year:  1991        PMID: 1681217     DOI: 10.1016/0140-6736(91)91504-n

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  13 in total

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