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Literature DB >> 16810989

Resistance of Salmonella typhi to chloramphenicol: Part II The mechanism of resistance.

Abstract

A study of the action of the culture filtrates of 10 strains of S. typhi resistant to chloramphenicol showed that two of the strains produced an extracellular substance which enabled a strain of S. typhi sensitive to chloramphenicol to grow in a mixture of the filtrate and the antibiotic. A study of the properties of this substance suggested that it was an enzyme.

Entities: Chemical Species

Year: 1962 PMID： 16810989 PMCID： PMC480456 DOI： 10.1136/jcp.15.6.548

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

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References

16 in total

1. Chloramphenicol-resistant strains of Salmonella typhosa. I. Induction of morphological, cultural, and antigenic changes.

Authors: L M WEINER; R E SWANSON
Journal: J Bacteriol Date: 1960-06 Impact factor: 3.490

2. Chloromycetin: Biological Studies.

Authors: R M Smith; D A Joslyn; O M Gruhzit; I W McLean; M A Penner; J Ehrlich
Journal: J Bacteriol Date: 1948-03 Impact factor: 3.490

3. Observations on the extracellular nature of staphylococcal penicillinase.

Authors: K R ERIKSEN; D HANSEN
Journal: Acta Pathol Microbiol Scand Date: 1954

4. Crossresistance to antibiotics; effect of repeated exposure of bacteria to aureomycin, terramycin, chloramphenicol or neomycin on the resistance to all of these antibiotics and to streptomycin and penicillin.

Authors: T M GOCKE; M FINLAND
Journal: J Lab Clin Med Date: 1951-11

Resistance of Salmonella typhi to chloramphenicol: Part II The mechanism of resistance.

1. Chloramphenicol-resistant strains of Salmonella typhosa. I. Induction of morphological, cultural, and antigenic changes.

2. Chloromycetin: Biological Studies.

3. Observations on the extracellular nature of staphylococcal penicillinase.

4. Crossresistance to antibiotics; effect of repeated exposure of bacteria to aureomycin, terramycin, chloramphenicol or neomycin on the resistance to all of these antibiotics and to streptomycin and penicillin.

5. Bacterial variants in patients treated with chloramphenicol.

6. Chloramphenicol-fastness: development in vivo and experimental production in vitro.

7. Resistance to chloramphenicol developing during treatment of typhoid fever.

8. Changes in bacterial sensitivity to aureomycin and chloramphenicol in the course of the past three years.

9. Penicillin inactivators of bacterial origin.

10. The decomposition of chloromycetin (chloramphenicol) by microorganisms.