Literature DB >> 1681079

Permeability of the blood-brain barrier for atenolol studied by positron emission tomography.

P Agon1, P Goethals, D Van Haver, J M Kaufman.   

Abstract

The permeability of the blood-brain barrier for atenolol, a hydrophilic beta-adrenergic blocking agent, has been assessed in dogs, by studying the distribution of [11C]atenolol in brain tissue with positron emission tomography. The passage of atenolol into the brain was very limited, but a measurable small net influx into the brain tissues did occur. Osmotic opening of the blood-brain barrier resulted in a marked increase of the atenolol concentrations in brain tissue. The approach described, with sequential non-invasive measurements in brain tissue, is applicable to pharmacokinetic studies of atenolol in man.

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Year:  1991        PMID： 1681079     DOI： 10.1111/j.2042-7158.1991.tb03545.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  15 in total

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