Literature DB >> 168106

The excretion of proinsulin and insulin in urine.

L Constan, M Mako, D Juhn, A H Rubenstein.   

Abstract

Proinsulin-like components (PLC) and insulin have been measured in 24 hr urine samples from 8 healthy subjects. The mean excretion of PLC was 45.8 ng and that of insulin 314 ng; the PLC: insulin ratio was 0.14. Urinary PLC was increased 3.5 fold in a patient with a pancreatic islet cell tumor and the PLC: insulin ratio was 0.35. The urinary PLC: insulin ratio is lower than that of serum, presumably because of the relatively lower urinary clearance of the larger molecular weight PLC.

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Year:  1975        PMID： 168106     DOI： 10.1007/bf00429834

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  21 in total

1.  Plasma proinsulin in patients with functioning pancreatic islet cell tumors.

Authors:  B M Sherman; S Pek; S S Fajans; J C Floyd; J W Conn
Journal:  J Clin Endocrinol Metab       Date:  1972-08       Impact factor: 5.958

2.  Urinary insulin excretion in healthy children and in siblings of childhood-onset diabetics.

Authors:  R G McArthur; L Stimmler
Journal:  Lancet       Date:  1966-06-04       Impact factor: 79.321

3.  Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide.

Authors:  P E Oyer; S Cho; J D Peterson; D F Steiner
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

4.  Radioimmunoassay of insulin in urine.

Authors:  A H Rubenstein; C Lowy; T R Fraser
Journal:  Diabetologia       Date:  1967-10       Impact factor: 10.122

5.  Human serum proinsulin.

Authors:  F Melani; A H Rubenstein; D F Steiner
Journal:  J Clin Invest       Date:  1970-03       Impact factor: 14.808

6.  Metabolism of proinsulin, insulin, and C-peptide in the rat.

Authors:  A I Katz; A H Rubenstein
Journal:  J Clin Invest       Date:  1973-05       Impact factor: 14.808

7.  Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein.

Authors:  P A Peterson; P E Evrin; I Berggård
Journal:  J Clin Invest       Date:  1969-07       Impact factor: 14.808

8.  Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli.

Authors:  P Gorden; J Roth
Journal:  J Clin Invest       Date:  1969-12       Impact factor: 14.808

9.  Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion.

Authors:  F Melani; W G Ryan; A H Rubenstein; D F Steiner
Journal:  N Engl J Med       Date:  1970-10-01       Impact factor: 91.245

10.  Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.

Authors:  P Gorden; B Sherman; J Roth
Journal:  J Clin Invest       Date:  1971-10       Impact factor: 14.808
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  3 in total

1.  The excretion of insulin in urine.

Authors:  R M El-Allawy; O Sonne; J Gliemann; H Orskov; K Johansen
Journal:  Diabetologia       Date:  1976-10       Impact factor: 10.122

2.  Residual B cell function in diabetic children as determined by urinary C-peptide.

Authors:  J Aurbach-Klipper; R Sharph-Dor; L G Heding; M Karp; Z Laron
Journal:  Diabetologia       Date:  1983-02       Impact factor: 10.122

3.  Amniotic fluid C-peptide in normal and insulin-dependent diabetic pregnancies.

Authors:  G Tchobroutsky; I Heard; C Tchobroutsky; E Eschwege
Journal:  Diabetologia       Date:  1980-04       Impact factor: 10.122
  3 in total

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