Literature DB >> 16809345

Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44.

Lingli Li1, Carl-Henrik Heldin, Paraskevi Heldin.   

Abstract

The extracellular matrix molecule hyaluronan was found to suppress platelet-derived growth factor (PDGF) beta-receptor activation and PDGF-BB-induced migration of primary human dermal fibroblasts. The suppressive effect of hyaluronan was neutralized by a monoclonal antibody that specifically inhibits hyaluronan binding to its receptor CD44. Moreover, co-immunoprecipitation experiments showed that the PDGF beta-receptor and CD44 can form a complex. Interestingly, the inhibitory effect of hyaluronan on PDGF beta-receptor activation was not seen in the presence of the tyrosine phosphatase inhibitor pervanadate. Our observations suggest that hyaluronan suppresses PDGF beta-receptor activation by recruiting a CD44-associated tyrosine phosphatase to the receptor.

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Year:  2006        PMID： 16809345     DOI： 10.1074/jbc.M605607200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  23 in total

1.  Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).

Authors:  Berit Bernert; Helena Porsch; Paraskevi Heldin
Journal:  J Biol Chem       Date:  2011-10-20       Impact factor: 5.157

2.  Differential activation of ERK and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44.

Authors:  Devashish Kothapalli; James Flowers; Tina Xu; Ellen Puré; Richard K Assoian
Journal:  J Biol Chem       Date:  2008-09-19       Impact factor: 5.157

Review 3.  Hyaluronan-CD44 interactions as potential targets for cancer therapy.

Authors:  Suniti Misra; Paraskevi Heldin; Vincent C Hascall; Nikos K Karamanos; Spyros S Skandalis; Roger R Markwald; Shibnath Ghatak
Journal:  FEBS J       Date:  2011-03-25       Impact factor: 5.542

4.  Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.

Authors:  Jennifer Velasco; Jun Li; Luisa DiPietro; Mary Ann Stepp; John D Sandy; Anna Plaas
Journal:  J Biol Chem       Date:  2011-05-12       Impact factor: 5.157

5.  Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other's signaling and stability.

Authors:  Helena Porsch; Merima Mehić; Berit Olofsson; Paraskevi Heldin; Carl-Henrik Heldin
Journal:  J Biol Chem       Date:  2014-05-23       Impact factor: 5.157

6.  Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment.

Authors:  Erika L Spaeth; Adam M Labaff; Bryan P Toole; Ann Klopp; Michael Andreeff; Frank C Marini
Journal:  Cancer Res       Date:  2013-07-09       Impact factor: 12.701

Review 7.  Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

Authors:  Carl-Henrik Heldin; Johan Lennartsson
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-08-01       Impact factor: 10.005

Review 8.  Rheostatic signaling by CD44 and hyaluronan.

Authors:  Ellen Puré; Richard K Assoian
Journal:  Cell Signal       Date:  2009-01-13       Impact factor: 4.315

9.  Development of drug loaded nanoparticles for tumor targeting. Part 1: Synthesis, characterization, and biological evaluation in 2D cell cultures.

Authors:  Mohammad H El-Dakdouki; Ellen Puré; Xuefei Huang
Journal:  Nanoscale       Date:  2013-03-26       Impact factor: 7.790

Review 10.  Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.

Authors:  Bryan P Toole; Mark G Slomiany
Journal:  Drug Resist Updat       Date:  2008-05-19       Impact factor: 18.500
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