Literature DB >> 16809220

A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice.

Gee Young Suh1, Hyoung Suk Ham, Shin-Hye Lee, Jae Chul Choi, Won-Jung Koh, Soo-Youl Kim, Jongmin Lee, Joungho Han, Hong Pyo Kim, Augustine M K Choi, O Jung Kwon.   

Abstract

Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

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Year:  2006        PMID： 16809220     DOI： 10.1080/01902140600691514

Source DB:  PubMed          Journal:  Exp Lung Res        ISSN： 0190-2148            Impact factor:   2.459


  9 in total

Review 1.  Roles of transglutaminases in cardiac and vascular diseases.

Authors:  David C Sane; Jimmy L Kontos; Charles S Greenberg
Journal:  Front Biosci       Date:  2007-01-01

Review 2.  Transglutaminase 2-mediated serotonylation in pulmonary hypertension.

Authors:  K C Penumatsa; B L Fanburg
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2013-12-27       Impact factor: 5.464

3.  Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.

Authors:  Bo Mi Ku; Se-Jin Kim; Nayeon Kim; Dongwan Hong; Yong-Bock Choi; Seon-Hyeong Lee; Young-Dae Gong; Soo-Youl Kim
Journal:  J Cancer Res Clin Oncol       Date:  2014-03-08       Impact factor: 4.553

4.  Anti-inflammatory effects of the R2 peptide, an inhibitor of transglutaminase 2, in a mouse model of allergic asthma, induced by ovalbumin.

Authors:  Dae Yong Kim; Bum Soo Park; Gwan Ui Hong; Byung Jae Lee; Jung Won Park; Soo Youl Kim; Jai Youl Ro
Journal:  Br J Pharmacol       Date:  2011-01       Impact factor: 8.739

Review 5.  The Outside-In Journey of Tissue Transglutaminase in Cancer.

Authors:  Livia Elena Sima; Daniela Matei; Salvatore Condello
Journal:  Cells       Date:  2022-05-29       Impact factor: 7.666

6.  A novel therapeutic target in inflammatory uveitis: transglutaminase 2 inhibitor.

Authors:  Joonhong Sohn; Ju Byung Chae; Sun Young Lee; Soo-Youl Kim; June-Gone Kim
Journal:  Korean J Ophthalmol       Date:  2010-02-05

7.  Transglutaminase II/microRNA-218/-181a loop regulates positive feedback relationship between allergic inflammation and tumor metastasis.

Authors:  Sangkyung Eom; Youngmi Kim; Misun Kim; Deokbum Park; Hansoo Lee; Yun Sil Lee; Jongseon Choe; Young Myeong Kim; Dooil Jeoung
Journal:  J Biol Chem       Date:  2014-09-08       Impact factor: 5.157

8.  Effects of transglutaminase 2 inhibition on ventilator-induced lung injury.

Authors:  In Bum Suh; Dae Wui Yoon; Won-Oak Oh; Eun Joo Lee; Kyung Hoon Min; Gyu Young Hur; Seung Heon Lee; Sung Yong Lee; Sang Yeub Lee; Chol Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Je Hyeong Kim
Journal:  J Korean Med Sci       Date:  2014-04-01       Impact factor: 2.153

Review 9.  Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death.

Authors:  H Tatsukawa; Y Furutani; K Hitomi; S Kojima
Journal:  Cell Death Dis       Date:  2016-06-02       Impact factor: 8.469
  9 in total

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