Literature DB >> 16809005

The mitogen-activated/extracellular signal-regulated kinase kinase 1/2 inhibitor U0126 induces glial fibrillary acidic protein expression and reduces the proliferation and migration of C6 glioma cells.

C R P Lind1, C W Gray, A G Pearson, R E Cameron, S J O'Carroll, P J Narayan, J Lim, M Dragunow.   

Abstract

The extracellular signal-regulated kinase (ERK) signaling pathway has been implicated in diverse cellular functions. ERK and its activating kinase, mitogen-activated/extracellular signal-regulated kinase kinase (MEK), are downstream of cell surface receptors known to be up-regulated in many malignant gliomas. We sought to investigate the role of ERK in glioma cell migration, proliferation and differentiation using the rat-derived C6 glioma cell line and the MEK inhibitor, U0126. Treatment of C6 cells with U0126 caused a significant concentration-dependent reduction in cell proliferation and migration and also induced expression of glial fibrillary acidic protein, a marker of astrocytic differentiation. These results suggest that the ERK pathway regulates glioma cell proliferation, migration and differentiation.

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Year:  2006        PMID： 16809005     DOI： 10.1016/j.neuroscience.2006.05.038

Source DB:  PubMed          Journal:  Neuroscience        ISSN： 0306-4522            Impact factor:   3.590


  9 in total

1.  Concurrent activation of β2-adrenergic receptor and blockage of GPR55 disrupts pro-oncogenic signaling in glioma cells.

Authors:  Artur Wnorowski; Justyna Such; Rajib K Paul; Robert P Wersto; Fred E Indig; Krzysztof Jozwiak; Michel Bernier; Irving W Wainer
Journal:  Cell Signal       Date:  2017-05-08       Impact factor: 4.315

2.  PDGFR inhibition mediated intracellular signalling in C6 glioma growth and migration: role of ERK and ROCK pathway.

Authors:  Juhi Singh; Kedarlal Sharma; Prakash P Pillai
Journal:  Cytotechnology       Date:  2017-11-15       Impact factor: 2.058

3.  Studying Human Brain Inflammation in Leptomeningeal and Choroid Plexus Explant Cultures.

Authors:  Mike Dragunow; Sheryl Feng; Justin Rustenhoven; Maurice Curtis; Richard Faull
Journal:  Neurochem Res       Date:  2015-08-05       Impact factor: 3.996

4.  Comprehensive analysis based on DNA methylation and RNA-seq reveals hypermethylation of the up-regulated WT1 gene with potential mechanisms in PAM50 subtypes of breast cancer.

Authors:  Chongyang Ren; Xiaojiang Tang; Haitao Lan
Journal:  PeerJ       Date:  2021-05-04       Impact factor: 2.984

Review 5.  Gangliosides as Signaling Regulators in Cancer.

Authors:  Norihiko Sasaki; Masashi Toyoda; Toshiyuki Ishiwata
Journal:  Int J Mol Sci       Date:  2021-05-11       Impact factor: 5.923

Review 6.  PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms.

Authors:  Franziska Briest; Patricia Grabowski
Journal:  Theranostics       Date:  2014-01-29       Impact factor: 11.556

7.  uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells.

Authors:  Kiranmai Alapati; Divya Kesanakurti; Jasti S Rao; Venkata Ramesh Dasari
Journal:  Stem Cell Res       Date:  2014-03-12       Impact factor: 2.020

8.  Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.

Authors:  Antonina Frolov; Ian M Evans; Ningning Li; Kastytis Sidlauskas; Ketevan Paliashvili; Nicola Lockwood; Angela Barrett; Sebastian Brandner; Ian C Zachary; Paul Frankel
Journal:  Sci Rep       Date:  2016-06-13       Impact factor: 4.379

9.  Overexpression of indoleamine 2, 3-dioxygenase contributes to the repair of human airway epithelial cells inhibited by dexamethasone via affecting the MAPK/ERK signaling pathway.

Authors:  Shanshan Jia; Pin Guo; Xiangjin Ge; Huanhuan Wu; Junhua Lu; Xiaofang Fan
Journal:  Exp Ther Med       Date:  2018-05-14       Impact factor: 2.447
  9 in total

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