| Literature DB >> 16808918 |
Ian M Overton1, Geoffrey J Barton.
Abstract
Target selection and ranking is fundamental to structural genomics. We present a Z-score scale, the "OB-Score", to rank potential targets by their predicted propensity to produce diffraction-quality crystals. The OB-Score is derived from a matrix of predicted isoelectric point and hydrophobicity values for nonredundant PDB entries solved to <or=3.0 A against a background of UniRef50. A highly significant difference was found between the OB-Scores for TargetDB test datasets. A wide range of OB-Scores was observed across 241 proteomes and within 7868 PfamA families; 73.4% of PfamA families contain >or=1 member with a high OB-Score, presenting favourable candidates for structural studies.Mesh：
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Year: 2006 PMID： 16808918 DOI： 10.1016/j.febslet.2006.06.015
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124