| Literature DB >> 16808914 |
Alexandra Peister1, Suzanne Zeitouni, Timothy Pfankuch, Roxanne L Reger, Darwin J Prockop, Jacob Raber.
Abstract
Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe(-/-)) mice were implanted into the cerebral ventricles of Apoe(-/-) mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.Entities:
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Year: 2006 PMID： 16808914 DOI： 10.1016/j.expneurol.2006.03.023
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330