Literature DB >> 16808730

Plumbism or lead intoxication mimicking an abdominal tumor.

Peter Dedeken1, Vernon Louw, Ann-Karolien Vandooren, Geert Verstegen, Willy Goossens, Bénédicte Dubois.   

Abstract

The clinical presentation of lead intoxication may vary widely and in the absence of a high clinical index of suspicion, the diagnosis may be missed. The effects of lead on mitochondrial oxidative phosphorylation and its interaction with calcium-mediated processes explain the heterogenous presentation. In this case report, the diagnosis was finally made when bilateral wrist drop developed on top of abdominal cramps and anemia. Before, ascites raised the suspicion of a tumor. Therefore, each element of the triad of unexplained anemia, abdominal cramps, and bilateral wrist (or foot) drop should lead any physician to consider the diagnosis of lead intoxication. This case also illustrates the importance of a careful and meticulous social history in patient management.

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Year:  2006        PMID: 16808730      PMCID: PMC1924641          DOI: 10.1111/j.1525-1497.2006.00328.x

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  4 in total

Review 1.  The lead-exposed worker.

Authors:  D Rempel
Journal:  JAMA       Date:  1989-07-28       Impact factor: 56.272

2.  Lead poisoning: case studies.

Authors:  J N Gordon; A Taylor; P N Bennett
Journal:  Br J Clin Pharmacol       Date:  2002-05       Impact factor: 4.335

3.  Kinetic analysis of lead metabolism in healthy humans.

Authors:  M B Rabinowitz; G W Wetherill; J D Kopple
Journal:  J Clin Invest       Date:  1976-08       Impact factor: 14.808

Review 4.  Lead poisoning.

Authors:  P J Landrigan; A C Todd
Journal:  West J Med       Date:  1994-08
  4 in total

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