OBJECTIVE: Delayed gastric emptying (GE) is common both in critical illness and in patients with diabetes mellitus (DM). The effect of DM on the incidence of slow GE in these patients is unknown. We evaluated the effect of DM on liquid GE in critically ill patients. METHODS: Retrospective analysis of GE using a standard [13C]octanoic acid breath test in 12 type 2 DM patients compared with (a) 44 critically ill patients without DM, including (b) a subgroup of 15 age- and sex-matched patients and (c) 15 healthy volunteers. We determined the gastric emptying coefficient (GEC) and the gastric half-emptying time (t50). Mean APACHE II scores, blood glucose levels and use of morphine were similar between patient groups. RESULTS: GE was faster in critically ill patients with DM (t50 122 +/- 11 min, GEC: 3.8 +/- 0.3) than in patients without DM (t50 168 +/- 16 min, GEC 2.8 +/- 0.1) and in age- and sex-matched controls (t50 165 +/- 13 min, GEC 2.7 +/- 0.2) and was similar to that in healthy volunteers (t50 148 +/- 13 min, GEC 3.5 +/- 0.1). The proportion of patients with slow emptying (GEC < 3.2) was greater in non-DM (all = 56%, matched = 60%) than in DM patients (25%) and healthy subjects (26%). CONCLUSION: Long-standing type diabetes mellitus is not a risk factor for slow GE in critically ill patients.
OBJECTIVE: Delayed gastric emptying (GE) is common both in critical illness and in patients with diabetes mellitus (DM). The effect of DM on the incidence of slow GE in these patients is unknown. We evaluated the effect of DM on liquid GE in critically illpatients. METHODS: Retrospective analysis of GE using a standard [13C]octanoic acid breath test in 12 type 2 DMpatients compared with (a) 44 critically illpatients without DM, including (b) a subgroup of 15 age- and sex-matched patients and (c) 15 healthy volunteers. We determined the gastric emptying coefficient (GEC) and the gastric half-emptying time (t50). Mean APACHE II scores, blood glucose levels and use of morphine were similar between patient groups. RESULTS: GE was faster in critically illpatients with DM (t50 122 +/- 11 min, GEC: 3.8 +/- 0.3) than in patients without DM (t50 168 +/- 16 min, GEC 2.8 +/- 0.1) and in age- and sex-matched controls (t50 165 +/- 13 min, GEC 2.7 +/- 0.2) and was similar to that in healthy volunteers (t50 148 +/- 13 min, GEC 3.5 +/- 0.1). The proportion of patients with slow emptying (GEC < 3.2) was greater in non-DM (all = 56%, matched = 60%) than in DMpatients (25%) and healthy subjects (26%). CONCLUSION: Long-standing type diabetes mellitus is not a risk factor for slow GE in critically illpatients.
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel De Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard Journal: Intensive Care Med Date: 2007-02-14 Impact factor: 17.440
Authors: Nam Q Nguyen; Robert J Fraser; Laura K Bryant; Marianne Chapman; Richard H Holloway Journal: World J Gastroenterol Date: 2007-01-14 Impact factor: 5.742
Authors: Adam Deane; Marianne J Chapman; Robert J Fraser; Laura K Bryant; Carly Burgstad; Nam Q Nguyen Journal: World J Gastroenterol Date: 2007-08-07 Impact factor: 5.742
Authors: Ross N Butler; Margaret Kosek; Nancy F Krebs; Cornelia U Loechl; Alexander Loy; Victor O Owino; Michael B Zimmermann; Douglas J Morrison Journal: J Pediatr Gastroenterol Nutr Date: 2017-01 Impact factor: 2.839
Authors: Nam Nguyen; Katrina Ching; Robert Fraser; Marianne Chapman; Richard Holloway Journal: Intensive Care Med Date: 2007-10-02 Impact factor: 17.440