Petr Bob1, Katerina Glaslova, Marek Susta, Denisa Jasova, Jiri Raboch. 1. Centre for Neuropsychiatric Research of Traumatic Stress, and Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. petrbob@netscape.net
Abstract
OBJECTIVES: According to recent evidence, trauma and stress are important etiological factors in pathogenesis of schizophrenia. However, the hypothetical influence of traumatic stress on epileptic-like (or kindling) phenomena in schizophrenia is at this time unclear. METHODS: In order to discover the influence of trauma, 82 patients with a diagnosis of paranoid schizophrenia and 50 healthy controls were assessed for symptoms of dissociation, traumatic stress and psycho-sensory symptoms of epileptic origin. RESULTS: We have found significant traumatization and dissociation in patients who met the cut-off score for psychosensory epileptic-like symptoms and also significant correlations among these measures have been found. CONCLUSIONS: These data suggest a certain role of epileptic-like phenomena in dissociative states in schizophrenia and are in accordance with rare intracranial EEG findings which suggest a certain role of epileptiform events in schizophrenia.
OBJECTIVES: According to recent evidence, trauma and stress are important etiological factors in pathogenesis of schizophrenia. However, the hypothetical influence of traumatic stress on epileptic-like (or kindling) phenomena in schizophrenia is at this time unclear. METHODS: In order to discover the influence of trauma, 82 patients with a diagnosis of paranoid schizophrenia and 50 healthy controls were assessed for symptoms of dissociation, traumatic stress and psycho-sensory symptoms of epileptic origin. RESULTS: We have found significant traumatization and dissociation in patients who met the cut-off score for psychosensory epileptic-like symptoms and also significant correlations among these measures have been found. CONCLUSIONS: These data suggest a certain role of epileptic-like phenomena in dissociative states in schizophrenia and are in accordance with rare intracranial EEG findings which suggest a certain role of epileptiform events in schizophrenia.
Authors: Patrícia Xavier L Gomes; Gersilene V de Oliveira; Fernanda Yvelize R de Araújo; Glauce Socorro de Barros Viana; Francisca Cléa F de Sousa; Thomas N Hyphantis; Neil E Grunberg; André F Carvalho; Danielle S Macêdo Journal: Psychopharmacology (Berl) Date: 2012-07-11 Impact factor: 4.530
Authors: Selwyn B Renard; Rafaele J C Huntjens; Paul H Lysaker; Andrew Moskowitz; André Aleman; Gerdina H M Pijnenborg Journal: Schizophr Bull Date: 2016-05-21 Impact factor: 9.306