| Literature DB >> 16807450 |
E Giovannetti1, R Danesi, V Mey, S Nannizzi, G Pasqualetti, M Del Tacca.
Abstract
The use of gemcitabine in combination with chemotherapeutic agents, including cisplatin, pemetrexed and taxanes, is characterized by the enhancement of their anticancer activity. The analysis of the underlying pharmacodynamics has revealed that modulation of nucleotide pools, drug metabolism, and cellular DNA repair capability are the most common factors to explain the additive to synergistic interaction between gemcitabine and anticancer agents in several human cancers in vitro and in vivo.Entities:
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Year: 2006 PMID： 16807450 DOI： 10.1093/annonc/mdj943
Source DB: PubMed Journal: Ann Oncol ISSN： 0923-7534 Impact factor: 32.976