Yingjie Cui1, Yaxian Dang, Yushe Yang, Shuhua Zhang, Ruyun Ji. 1. Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences Shanghai 201203, China. cuiyingjie@yahoo.com
Abstract
OBJECTIVES AND METHODS: YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined. RESULTS: YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid. CONCLUSIONS: This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.
OBJECTIVES AND METHODS: YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined. RESULTS:YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid. CONCLUSIONS: This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.