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Literature DB >> 16806949

Captive solvent [11C]acetate synthesis in GMP conditions.

Abstract

Reliable procedure for the production of 1-[(11)C]acetate in GMP conditions was developed based on a combination of the captive-solvent Grignard reaction conducted in the sterile catheter followed by the convenient solid-phase extraction purification on a series of ion-exchange cartridges. The described procedure proved to be reliable in more than 30 patient productions. The process provides stable radiochemical yields (65% EOB) of sodium acetate (1-[(11)C]) of the Ph.Eur. quality (radiochemical purity better than 95%) in a short time (5 min).

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Year: 2006 PMID： 16806949 DOI： 10.1016/j.apradiso.2006.04.011

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

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Cited

7 in total

1. Fast and repetitive in-capillary production of [18F]FDG.

Authors: Hans-Jürgen Wester; Bent Wilhelm Schoultz; Christina Hultsch; Gjermund Henriksen
Journal: Eur J Nucl Med Mol Imaging Date: 2008-11-27 Impact factor: 9.236

2. (11)C-acetate PET in the early evaluation of prostate cancer recurrence.

Authors: Susanne Albrecht; Franz Buchegger; Dmitri Soloviev; Habib Zaidi; Hansjoerg Vees; Haleem G Khan; Alain Keller; Angelika Bischof Delaloye; Osman Ratib; Raymond Miralbell
Journal: Eur J Nucl Med Mol Imaging Date: 2006-07-11 Impact factor: 9.236

3. Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.

Authors: Yukie Yoshii; Takako Furukawa; Nobuyuki Oyama; Yoko Hasegawa; Yasushi Kiyono; Ryuichi Nishii; Atsuo Waki; Atsushi B Tsuji; Chizuru Sogawa; Hidekatsu Wakizaka; Toshimitsu Fukumura; Hiroshi Yoshii; Yasuhisa Fujibayashi; Jason S Lewis; Tsuneo Saga
Journal: PLoS One Date: 2013-05-31 Impact factor: 3.240

4. [¹¹C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.

Authors: Franz Buchegger; Osman Ratib; Jean-Pierre Willi; Charles Steiner; Yann Seimbille; Habib Zaidi; Véronique Graf; Robin Peter; Maximilien Jung
Journal: Mol Imaging Biol Date: 2010-08-31 Impact factor: 3.488

Captive solvent [11C]acetate synthesis in GMP conditions.

1. Fast and repetitive in-capillary production of [18F]FDG.

2. (11)C-acetate PET in the early evaluation of prostate cancer recurrence.

3. Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.

4. [¹¹C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.

5. A new concept for the production of ¹¹C-labelled radiotracers.

6. In-house development of an optimized synthetic module for routine [11C]acetate production.

7. Synthesis, isolation and purification of [(11)C]-choline.