| Literature DB >> 16806946 |
Weiqin Jiang1, George Allan, James J Fiordeliso, Olivia Linton, Pamela Tannenbaum, Jun Xu, Peifang Zhu, Joseph Gunnet, Keith Demarest, Scott Lundeen, Zhihua Sui.
Abstract
A new series of phosphorus-containing 11beta-aryl-substituted steroids have been synthesized in an eight-step sequence involving a palladium-catalyzed coupling reaction to introduce a phosphorus group onto the aromatic ring. The compounds were evaluated for progesterone receptor (PR) antagonist activity in a T47D cell-based assay and for glucocorticoid receptor (GR) antagonist activity in an A549 cell-based assay. The structure-activity relationships of these compounds are discussed. Selected compounds were tested in vivo in a rat complement C3 assay.Entities:
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Year: 2006 PMID： 16806946 DOI： 10.1016/j.bmc.2006.05.066
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641